Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics
- Author(s)
- Bogumila Kupcewicz, Krzysztof Sobiesiak, Katarzyna Malinowska, Kamila Koprowska, Malgorzata Czyz, Bernhard Keppler, Elzbieta Budzisz
- Abstract
A series of six mononuclear Cu(II) complexes with pyrazole-based ligands: 5-(2-hydroxybenzoyl)-3-methyl-1-(2-pyridinyl)-1H-pyrazol-4-phosphonic acid dimethyl ester (1a), 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-carboxylic acid methyl ester (1b) and 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1c) were characterized regarding to electrochemical and antioxidant properties. All complexes exhibit suitable Cu(II)/Cu(I) redox potential (E (1/2)) to act as antioxidant enzymes mimic. The five of these complexes were found to be trifunctional enzyme mimics possessing SOD, CAT and GPx-like catalytic activities. Moreover, Cu(II) complexes were capable to decrease ROS level in melanoma cells and observed effects were not merely a reflection of cytotoxicity.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Nicolaus Copernicus University, Medical University of Lodz
- Journal
- Medicinal Chemistry Research: an international journal for rapid communications on design and mechanisms of action of biologically active agents
- Volume
- 22
- Pages
- 2395-2402
- No. of pages
- 8
- ISSN
- 1054-2523
- DOI
- https://doi.org/10.1007/s00044-012-0233-5
- Publication date
- 2013
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301206 Pharmacology, 301305 Medical chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/a81cac25-1599-41a2-af57-1ca7396b3c20