Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton

Author(s)
Yasmin Borutzki, Lukas Skos, Christopher Gerner, Samuel M. Meier-Menches
Abstract

During recent years, accumulating evidence suggested that metal-based candidate drugs are promising modulators of cytoskeletal and cytoskeleton-associated proteins. This was substantiated by the identification and validation of actin, vimentin and plectin as targets of distinct ruthenium(II)- and platinum(II)-based modulators. Despite this, structural information about molecular interaction is scarcely available. Here, we compile the scattered reports about metal-based candidate molecules that influence the cytoskeleton, its associated proteins and explore their potential to interfere in cancer-related processes, including proliferation, invasion and the epithelial-to-mesenchymal transition. Advances in this field depend crucially on determining binding sites and on gaining comprehensive insight into molecular drug-target interactions. These are key steps towards establishing yet elusive structure-activity relationships.

Organisation(s)
Department of Inorganic Chemistry, Department of Analytical Chemistry, Joint Metabolome Facility, Mass Spectrometry Centre
External organisation(s)
Vienna Doctoral School in Chemistry (DoSChem)
Journal
ChemBioChem
Volume
24
ISSN
1439-4227
DOI
https://doi.org/10.1002/cbic.202300178
Publication date
09-2023
Peer reviewed
Yes
Austrian Fields of Science 2012
106002 Biochemistry, 106023 Molecular biology, 301305 Medical chemistry
Keywords
ASJC Scopus subject areas
Biochemistry, Molecular Medicine, Molecular Biology, Organic Chemistry
Sustainable Development Goals
SDG 3 - Good Health and Well-being
Portal url
https://ucrisportal.univie.ac.at/en/publications/a8988267-28d4-4687-8a96-a0e467057173