Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton
- Author(s)
- Yasmin Borutzki, Lukas Skos, Christopher Gerner, Samuel M. Meier-Menches
- Abstract
During recent years, accumulating evidence suggested that metal-based candidate drugs are promising modulators of cytoskeletal and cytoskeleton-associated proteins. This was substantiated by the identification and validation of actin, vimentin and plectin as targets of distinct ruthenium(II)- and platinum(II)-based modulators. Despite this, structural information about molecular interaction is scarcely available. Here, we compile the scattered reports about metal-based candidate molecules that influence the cytoskeleton, its associated proteins and explore their potential to interfere in cancer-related processes, including proliferation, invasion and the epithelial-to-mesenchymal transition. Advances in this field depend crucially on determining binding sites and on gaining comprehensive insight into molecular drug-target interactions. These are key steps towards establishing yet elusive structure-activity relationships.
- Organisation(s)
- Department of Inorganic Chemistry, Department of Analytical Chemistry, Joint Metabolome Facility, Mass Spectrometry Centre
- External organisation(s)
- Vienna Doctoral School in Chemistry (DoSChem)
- Journal
- ChemBioChem
- Volume
- 24
- ISSN
- 1439-4227
- DOI
- https://doi.org/10.1002/cbic.202300178
- Publication date
- 09-2023
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 106002 Biochemistry, 106023 Molecular biology, 301305 Medical chemistry
- Keywords
- ASJC Scopus subject areas
- Biochemistry, Molecular Medicine, Molecular Biology, Organic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/a8988267-28d4-4687-8a96-a0e467057173