Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands
- Author(s)
- Eva Anna Enyedy, Orsolya Domotor, Erika Varga, Lamas Kiss, Robert Trondl, Christian G. Hartinger, Bernhard Keppler
- Abstract
The stoichiometry and stability constants of the Ga(III) complexes of 8-hydroxyquinoline (HQ), 8-hydroxyquinoline-5-sulfonate (HQS), maltol, thiomaltol, allomaltol and thioallomaltol were determined by means of pH-potentiometry, UV-vis spectrophotometry, spectrofluorometry and H-1 NMR spectroscopy in aqueous solution. Spectrofluorometry was used to determine the stability constants of the Ga(III)-HQ species in water. Formation of [GaL](2+), [GaL2](+) and [GaL3] complexes was found and the Ga(III) binding ability of the ligands followed the order: thioallomaltol
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Szeged, University of Auckland
- Journal
- Journal of Inorganic Biochemistry
- Volume
- 117
- Pages
- 189-197
- No. of pages
- 9
- ISSN
- 0162-0134
- DOI
- https://doi.org/10.1016/j.jinorgbio.2012.08.005
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 106002 Biochemistry, 301 Medical-Theoretical Sciences, Pharmacy
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/abb8cf9e-4757-4258-bb6b-e7030ce7ce0e