L-[S-methyl-C-11]methionine - An example of radiosynthetic optimization
- Author(s)
- V. Pichler, C. Vraka, N. Berroterán-Infante, A. Krcal, H. Eidherr, T. Traub-Weidinger, M. Hacker, M. Mitterhauser, W. Wadsak
- Abstract
Radiosynthetic optimization is crucial in routine PET production but is often neglected in literature. Small changes in the radiochemical procedure can increase the yield significantly and reduce time fluctuation within the synthetic procedure enabling better planning and product release on time. Therefore, a highly reproducible production method for L-[S-methyl-
11C]methionine is presented, which uses a fully automated GE TRACERlab FX C Pro synthesizer. Evolution of the synthetic procedure lead to a protocol with a nearly doubled absolute yield.
- Organisation(s)
- External organisation(s)
- Medizinische Universität Wien, Ludwig Boltzmann Intitute Applied Diagnostics, Centre for Biomarker Research in Medicine – CBmed GmbH
- Journal
- Applied Radiation and Isotopes
- Volume
- 141
- Pages
- 107-111
- No. of pages
- 5
- ISSN
- 0969-8043
- DOI
- https://doi.org/10.1016/j.apradiso.2018.08.021
- Publication date
- 11-2018
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104020 Radiochemistry
- Keywords
- ASJC Scopus subject areas
- Radiation
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/ac071fcb-b12d-4b39-bf8d-5cbe0ee53918