Water-Soluble Cationic Derivatives of Indirubin, the Active Anticancer Component from Indigo naturalis
- Author(s)
- Werner Ginzinger, Alexander Egger, Gerhard Mühlgassner, Vladimir Arion, Michael Jakupec, Mathea Sophia Galanski, Walter Berger, Bernhard Keppler
- Abstract
To overcome the problem of poor aqueous solubility and bioavailability of indirubin-3-oximes, the compounds were modified by attaching a quaternary ammonium group at the oxime moiety. Exploring the prodrug concept, an oxime ester with acetyl-l-carnitine was prepared, and the rate of its hydrolysis was investigated to assess its suitability for clinical administration. In addition, the cytotoxic potency of new stable oxime ethers with a choline moiety and their influence on the cell cycle were tested in human cancer cell lines.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Medizinische Universität Wien
- Journal
- Chemistry & Biodiversity
- Volume
- 9
- Pages
- 2175-2185
- No. of pages
- 11
- ISSN
- 1612-1872
- DOI
- https://doi.org/10.1002/cbdv.201200147
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301 Medical-Theoretical Sciences, Pharmacy
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/af601435-9f9f-4adb-bc7e-2eef73011d12