Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[(11)C]methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB)
- Author(s)
- Cecile Philippe, Daniela Haeusler, Markus Mitterhauser, Johanna Ungersböck, Helmut Viernstein, Robert Dudczak, Wolfgang Wadsak
- Abstract
[(11)C]PIB is still the standard PET compound for Alzheimer imaging targeting beta-amyloid plaques. We aimed to establish a fully-automated procedure for the synthesis and purification of [(11)C]PIB with a high degree of reliability and improved specific activity as well as a suitable and fast quality control assay. The optimum reaction conditions were 75 degrees C, 4 mg/mL precursor yielding at 48.0 +/- 2.7% (EOS, based on [(11)C]CH(3)OTf, corrected for decay), 183 +/- 14 GBq/mu mol specific activity and >99% radiochemical purity. Time consumption was kept to a minimum (40 min from EOB) and overall yields were enough to serve 2 consecutive patients with a single preparation.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Medizinische Universität Wien
- Journal
- Applied Radiation and Isotopes
- Volume
- 69
- Pages
- 1212-1217
- No. of pages
- 6
- ISSN
- 0969-8043
- DOI
- https://doi.org/10.1016/j.apradiso.2011.04.010
- Publication date
- 2011
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301208 Pharmaceutical technology
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/b200d4f6-3cd9-490c-97a7-c5292925bfb6