Novel endothall containing platinum(IV) complexes - synthesis, characterization, and cytotoxic activity
- Author(s)
- Michael Reithofer, Seied Mojtaba Valiahdi, Mathea Sophia Galanski, Michael Jakupec, Vladimir Arion, Bernhard Keppler
- Abstract
Two platinum(IV) complexes (OC-6-33)-dichlorido(ethane-1,2-diamine)dihydroxidoplatinum(IV) and (OC-6-33)-diammine(dichloridodihydroxido-platinum(IV) were carboxylated using demethylcantharidin as carboxylation agent. The complexes were characterized by elemental analysis, mass spectrometry, multinuclear (1H, 13C, 15N, and 195Pt) NMR spectroscopy, and, in case of (OC-6-33)-diamminebis(3-carboxy-7exo-oxabicyclo[2.2.1]heptane-2-carboxylato)dichloridoplatinum(IV) via X-ray
diffraction. Cytotoxicity of the complexes was studied in seven human cancer cell lines representing five tumor entities, i.e., ovarian carcinoma (CH1, SK-OV-3), cervical carcinoma (HeLa), colon carcinoma (SW480, HCT-116), osteosarcoma (U-2 OS), and hepatocellular carcinoma (Hep G2) by means of the MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium hydrobromide) assay.
- Organisation(s)
- Department of Inorganic Chemistry
- Journal
- Chemistry & Biodiversity
- Volume
- 5
- Pages
- 2160-2170
- No. of pages
- 11
- ISSN
- 1612-1872
- Publication date
- 2008
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/b510a05c-e612-443a-96fe-b7a1e45938de