In vitro evaluation of no carrier added, carrier added and cross-complexed [90Y]-EDTMP provides evidence for a novel "foreign carrier theory"

Author(s): Stefan Tögel, Leonhard-Key Mien, Wolfgang Wadsak, Harald Eidherr, Helmut Viernstein, Rainer Kluger, Dagmar Ettlinger, Kurt Kletter, Robert Dudczak, Markus Mitterhauser
Abstract: The present study focused on the preparation of novel bone tracers containing yttrium as radionuclide or carrier. Moreover, these preparations were comparatively evaluated in vitro on the basis of a recently presented pre vivo model comprising binding studies on synthetic and human bone powder. It was shown that among the therapeutic radionuclides, no carrier added [ 90Y]-EDTMP exceeded [188Re]-EDTMP while yielding lower binding values than [153Sm]-EDTMP. Furthermore, the authors investigated the influence of "foreign" carriers added to [ 90Y]-EDTMP, [99mTc]-EDTMP and [111In]-EDTMP by the method of cross-complexation. The findings reveal a new paradigm: a carrier more foreign to the complexed radionuclide causes a higher binding increase on human bone matrices in vitro than a more "related" carrier. Œ 2006 Elsevier Inc. All rights reserved.
Organisation(s): Department of Inorganic Chemistry, Department of Sport and Human Movement Science
External organisation(s): Sozialmedizinisches Zentrum Ost - Donauspital
Journal: Nuclear Medicine and Biology
Volume: 33
Pages: 95-99
No. of pages: 5
ISSN: 0969-8051
Publication date: 2006
Peer reviewed: Yes
Austrian Fields of Science 2012: 3012 Pharmacy, Pharmacology, Toxicology
Portal url: https://ucrisportal.univie.ac.at/en/publications/9030fac4-9f7f-472d-b8f0-d9dad39cc833