Bis- and Tetrakis(carboxylato)platinum(IV) Complexes with Mixed Axial Ligands - Synthesis, Characterization, and Cytotoxicity
- Author(s)
- Bjoern R. Hoffmeister, Michaela Hejl, Mahsa S. Adib-Razavi, Michael A. Jakupec, Mathea Sophia Galanski, Bernhard K. Keppler
- Abstract
A series of twelve novel diamminetetrakis(carboxylato)platinum(IV) and 18 novel bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) complexes with mixed axial carboxylato ligands was synthesized and characterized by multinuclear 1H-, 13C-, 15N-, and 195Pt-NMR spectroscopy. Their cytotoxic potential was evaluated (by MTT assay) against three human cancer cell lines derived from ovarian teratocarcinoma (CH1/PA-1), lung (A549), and colon carcinoma (SW480). In the cisplatin-sensitive CH1/PA-1 cancer cell line, diamminetetrakis(carboxylato)platinum(IV) complexes showed IC50 values in the low micromolar range, whereas, for the most lipophilic compounds of the bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) series, IC50 values in the nanomolar range were found.
- Organisation(s)
- Department of Inorganic Chemistry, NMR Centre
- Journal
- Chemistry & Biodiversity
- Volume
- 12
- Pages
- 559-574
- No. of pages
- 16
- ISSN
- 1612-1872
- DOI
- https://doi.org/10.1002/cbdv.201400291
- Publication date
- 04-2015
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301904 Cancer research, 106002 Biochemistry, 106023 Molecular biology
- Keywords
- ASJC Scopus subject areas
- Bioengineering, General Chemistry, Molecular Medicine, Molecular Biology, Biochemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/b7fa2f01-0362-467b-9dd7-8dd902c47256