Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux
- Author(s)
- Julia H. Bormio Nunes, Sonja Hager, Marlene Mathuber, Vivien Pósa, Alexander Roller, Eva A. Enyedy, Alessia Stefanelli, Walter Berger, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
- Organisation(s)
- Department of Inorganic Chemistry, Core Facility Crystal Structure Analysis
- External organisation(s)
- Medizinische Universität Wien, University of Szeged, Universidade Estadual de Campinas, University of Vienna
- Journal
- Journal of Medicinal Chemistry
- Volume
- 63
- Pages
- 13719-13732
- No. of pages
- 14
- ISSN
- 0022-2623
- DOI
- https://doi.org/10.1021/acs.jmedchem.0c01277
- Publication date
- 11-2020
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301305 Medical chemistry, 301904 Cancer research
- ASJC Scopus subject areas
- Molecular Medicine, Drug Discovery
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/c778d63a-ac97-47ec-a922-ec4ab2fc546f