Quinolone antibacterial agents linked to osteotropic bisphosphonate moieties
- Author(s)
- Thomas Pieper, Bernhard Keppler
- Abstract
Bisphosphonates are widely used in diagnosis and therapy of different bone diseases. Due to their potential to accumulate in the inorganic bone matrix hydroxylapatite they are useful agents in osteotic vectorization of different types of drugs. We linked bisphosphonate moieties to antibacterial quinolones like norfloxacin to enable a selective targeting of these agents to bone tissue. The quinolones (1,4-dihydro-4-oxo-quinoline-3-carboxylic acids) were modified at position 1 and 7 using alkylbisphosphonates with ethene-, amino- and carboxylic-groups. After coupling with the quinolones, the alkylbisphosphonic esters could smoothly be hydrolyzed via the corresponding silyl esters to obtain the free bisphosphonic acids.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Vienna
- Journal
- Phosphorus, Sulfur and Silicon and the Related Elements
- Volume
- 170
- Pages
- 5-14
- No. of pages
- 10
- ISSN
- 1042-6507
- DOI
- https://doi.org/10.1080/10426500108040581
- Publication date
- 2001
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 1040 Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/bf27f2a6-fb83-40ad-b7fa-9c62744d2187