DNA or protein? Capillary zone electrophoresismass spectrometry rapidly elucidates metallodrug binding selectivity
- Author(s)
- Christian Artner, Hannah U. Holtkamp, Wolfgang Kandioller, Christian G. Hartinger, Samuel Matthias Meier, Bernhard K. Keppler
- Abstract
A novel capillary zone electrophoresis-mass spectrometry (CZE-MS) approach allows the simultaneous characterization and quantification of the binding of metal-based anticancer agents to biomolecules. Moreover, for the first time, oligonucleotide metallation was resolved at single-nucleotide resolution by MS.
- Organisation(s)
- Department of Inorganic Chemistry, Department of Analytical Chemistry
- External organisation(s)
- University of Auckland
- Journal
- Chemical Communications
- Volume
- 53
- Pages
- 8002-8005
- No. of pages
- 4
- ISSN
- 1359-7345
- DOI
- https://doi.org/10.1039/c7cc04582d
- Publication date
- 07-2017
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 104002 Analytical chemistry
- Keywords
- ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials, Ceramics and Composites, Metals and Alloys, Materials Chemistry, Surfaces, Coatings and Films, General Chemistry, Catalysis
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/c62fb5b2-6098-47ab-afb2-fe0b64e35058