Ionic liquid-mediated drug delivery: A review on progress and challenges focused on poly(ionic liquid) nanoplatforms
- Author(s)
- Magdalena Matczuk, Andrei R. Timerbaev, Bernhard K. Keppler, Lena Ruzik
- Abstract
Ionic liquids (ILs) have a long and successful history of application as materials of special interest in various fields, particularly in biomedicine. When polymerized at the nanoscale, polymeric ILs (PILs) combine the attractive properties of ILs with the united advantages of solid polymer structures and nanoparticulate matter. As rapidly developing nanomaterials of biomedical importance, they afford new prospects for the treatment of various diseases. In particular, due to their greatly tunable composition, biocompatibility and wide specific surface area, the PIL nanoparticles offer potential as delivery systems for different medications. This brief review introduces the emerging landscape of drug-delivery PIL systems and summarizes their actual and potential applications available from recent literature (after 2018). Special attention is paid to the different methods of fabricating the nano-sized PILs and their properties responsible for controlled drug release. Critically discussed are diverse examples of using nanostructures based on PILs with variable morphology designed as drug-vehicle vectors. Also brought into focus are the challenges in the preclinical development of and future perspectives on PIL nanocarriers.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Warsaw University of Technology
- Journal
- Journal of Molecular Liquids
- Volume
- 399
- ISSN
- 0167-7322
- DOI
- https://doi.org/10.1016/j.molliq.2024.124403
- Publication date
- 04-2024
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104017 Physical chemistry, 104011 Materials chemistry, 301208 Pharmaceutical technology
- Keywords
- ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials, Atomic and Molecular Physics, and Optics, Condensed Matter Physics, Spectroscopy, Physical and Theoretical Chemistry, Materials Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/ca034e74-c1ce-45c7-a4d3-9184a57f08d2