Towards targeting anticancer drugs
- Author(s)
- Mario Kubanik, Wolfgang Kandioller, Kunwoo Kim, Robert F. Anderson, Erik Klapproth, Michael A. Jakupec, Alexander Roller, Tilo Sohnel, Bernhard K. Keppler, Christian G. Hartinger
- Abstract
Anticancer active metal complexes with biologically active ligands have the potential to interact with more than one biological target, which could help to overcome acquired and/or intrinsic resistance of tumors to small molecule drugs. In this paper we present the preparation of 2-hydroxy-[1,4]-naphthoquinone-derived ligands and their coordination to a Ru
II(η
6-p-cymene)Cl moiety. The synthesis of oxime derivatives resulted in the surprising formation of nitroso-naphthalene complexes, as confirmed by X-ray diffraction analysis. The compounds were shown to be stable in aqueous solution but reacted with glutathione and ascorbic acid rather than undergoing reduction. One-electron reduction with pulse radiolysis revealed different behavior for the naphthoquinone and nitroso-naphthalene complexes, which was also observed in in vitro anticancer assays.
- Organisation(s)
- Department of Inorganic Chemistry, Core Facility Crystal Structure Analysis
- External organisation(s)
- University of Auckland
- Journal
- Dalton Transactions
- Volume
- 45
- Pages
- 13091-13103
- No. of pages
- 13
- ISSN
- 1477-9226
- DOI
- https://doi.org/10.1039/c6dt01110a
- Publication date
- 09-2016
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301904 Cancer research
- Keywords
- ASJC Scopus subject areas
- Inorganic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/ca2c7bf7-eb4d-4546-abdd-d5cddb9637d0