Ruthenium- and osmium-arene complexes of 8-substituted indolo[3,2-c] quinolines: Synthesis, X-ray diffraction structures, spectroscopic properties, and antiproliferative activity
- Author(s)
- Lukas Filak, Simone Göschl, Stefanie Hackl, Michael Jakupec, Vladimir Arion
- Abstract
Six novel ruthenium(II)- and osmium(II)-arene complexes with indoloquinoline modified ligands containing methyl and halo substituents in position 8 of the molecule backbone have been synthesised and comprehensively characterised by spectroscopic methods ( 1H, 13C NMR, UV-Vis), ESI mass spectrometry and X-ray crystallography. Binding of indoloquinolines to a metal-arene scaffold makes the products soluble enough in biological media to allow for assaying their antiproliferative activity. The complexes were tested in three human cancer cell lines, namely A549 (non-small cell lung cancer), SW480 (colon carcinoma) and CH1 (ovarian carcinoma), yielding IC 50 values in the 10 -6-10 -7 M concentration range after continuous exposure for 96 h. Compounds with halo substituents in position 8 are more effective cytotoxic agents in vitro than the previously reported species halogenated in position 2 of the indoloquinoline backbone. High antiproliferative activity of both series of substances may be due at least in part to their potential to act as DNA intercalators
- Organisation(s)
- Department of Inorganic Chemistry
- Journal
- Inorganica Chimica Acta
- Volume
- 393
- Pages
- 252-260
- No. of pages
- 9
- ISSN
- 0020-1693
- DOI
- https://doi.org/10.1016/j.ica.2012.06.004
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/cbe23ede-8adc-4a0b-a022-1ecc650e5c3f