Influence of the spacer length on the in vitro anticancer activity of dinuclear ruthenium-arene compounds
- Author(s)
- Maria Grazia Mendoza Parra Ferri, Christian Hartinger, Rene Eichinger, Natalia Stolyarova, Kay Severin, Michael Jakupec, Alexey Nazarov, Bernhard Keppler
- Abstract
Water soluble dinuclear Ru-arene complexes were synthesized and found to exert promising cytotoxic effects in human cancer cells, which could be increased to an IC50 of 0.5 M by increasing the spacer length between the metal centers. Cytotoxicity could be correlated with lipophilicity (log P values) and water solubility. The most potent dinuclear compound, 1,12-bis{chlorido[3-(oxo-κO)-2-methyl-4-pyridinonato-κO4](η6-p-isopropyltoluene)ruthenium}dodecane 4c, is at least 2¿3 orders of magnitude more active than the mononuclear analogue chlorido[3-(oxo-κO)-2-methyl-4-pyronato-κO4](η6-p-isopropyltoluene)ruthenium.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- École polytechnique fédérale de Lausanne
- Journal
- Organometallics
- Volume
- 27
- Pages
- 2405-2407
- No. of pages
- 3
- ISSN
- 0276-7333
- Publication date
- 2008
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/dde8f2ee-c76a-4355-a7a7-2b1f0617d8da