Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods
- Author(s)
- Johanna Ungersböck, Cecile Philippe, Daniela Haeusler, Markus Mitterhauser, Rupert Lanzenberger, Robert Dudczak, Wolfgang Wadsak
- Abstract
The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed "aging" effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6% (EOB; 5.2 +/- 0.95 GBq EOS).
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Medizinische Universität Wien
- Journal
- Applied Radiation and Isotopes
- Volume
- 70
- Pages
- 2615-2620
- No. of pages
- 6
- ISSN
- 0969-8043
- DOI
- https://doi.org/10.1016/j.apradiso.2012.08.001
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 302054 Nuclear medicine, 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/dfb634c2-a716-4d8d-92a3-f7ed6d1ac2aa