Capillary electrophoresis of platinum-group elements: Analytical, speciation and biochemical studies
- Author(s)
- Bernhard Keppler, Andrei Timerbaev
- Abstract
A great deal of research has been carried out in recent years on developing high-efficiency capillary electrophoresis (CE) techniques that are able to separate rapidly and selectively ionic platinum metal species in a wide variety of their complexed forms. Using a range of illustrative examples, this review examines the potential and utilization of various CE separation approaches and detection modes in this expanding area. Also covered are CE procedures suitable for solving practical analytical problems and for platinum metal speciation purposes. Presenting a comprehensive treatise on the evolving practices of CE concerning platinum anticancer drugs - in particular, the examination of the stability of intact drugs, the separation and identification of products of their metabolism and interactions with biomolecules (including kinetic studies of the binding behavior) - this paper witnesses a welcome shift of the main research activities to those performed under physiological conditions. Π2002 Elsevier Science B.V. All rights reserved.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Russian Academy of Sciences
- Journal
- Journal of Chromatography A
- Volume
- 945
- Pages
- 25-44
- No. of pages
- 20
- ISSN
- 0021-9673
- DOI
- https://doi.org/10.1016/S0021-9673(01)01489-3
- Publication date
- 2002
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 1040 Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/e0a04d88-fe1e-4a16-a339-4851ffe872e9