Towards Ruthenium(II)-Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy
- Author(s)
- Youchao Wang, Patrick S. Felder, Pierre Mesdom, Olivier Blacque, Thomas L. Mindt, Kevin Cariou, Gilles Gasser
- Abstract
The search for new metal-based photosensitizers (PSs) for anticancer photodynamic therapy (PDT) is a fast-developing field of research. Knowing that polymetallic complexes bear a high potential as PDT PSs, in this study, we aimed at combining the known photophysical properties of a rhenium(I) tricarbonyl complex and a ruthenium(II) polypyridyl complex to prepare a ruthenium-rhenium binuclear complex that could act as a PS for anticancer PDT. Herein, we present the synthesis and characterization of such a system and discuss its stability in aqueous solution. In addition, one of our complexes prepared, which localized in mitochondria, was found to have some degree of selectivity towards two types of cancerous cells: human lung carcinoma A549 and human colon colorectal adenocarcinoma HT29, with interesting photo-index (PI) values of 135.1 and 256.4, respectively, compared to noncancerous retinal pigment epithelium RPE1 cells (22.4).
- Organisation(s)
- Department of Inorganic Chemistry, Joint Applied Medicinal Radiochemistry Facility
- External organisation(s)
- Universität Zürich (UZH), Medizinische Universität Wien, l'Université PSL
- Journal
- ChemBioChem
- Volume
- 24
- ISSN
- 1439-4227
- DOI
- https://doi.org/10.1002/cbic.202300467
- Publication date
- 10-2023
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301303 Medical biochemistry
- Keywords
- ASJC Scopus subject areas
- Biochemistry, Molecular Medicine, Molecular Biology, Organic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/e16a2f4b-57a6-4c4a-95aa-8cca3f45774b