Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes
- Author(s)
- Muhammad Hanif, Samuel Matthias Meier, Alexey A. Nazarov, Julie Risse, Anton Legin, Angela Casini, Michael Jakupec, Bernhard Keppler, Christian G. Hartinger
- Abstract
The synthesis and in vitro cytotoxicity of a series of RuII(arene) complexes with carbohydrate-derived phosphite ligands and various arene co-ligands is described. The arene ligand has a strong influence on the in vitro anticancer activity of this series of compounds, which correlates fairly well with cellular accumulation. The most lipophilic compound bearing a biphenyl moiety and a cyclohexylidene-protected carbohydrate is the most cytotoxic with unprecedented IC50 values for the compound class in three human cancer cell lines. This compound shows reactivity to the DNA model nucleobase 9-ethylguanine, but does not alter the secondary structure of plasmid DNA, indicating that other biological targets are responsible for its cytotoxic effect.
- Organisation(s)
- Department of Analytical Chemistry, Department of Inorganic Chemistry
- External organisation(s)
- University of Auckland, University of Groningen, École polytechnique fédérale de Lausanne
- Journal
- Frontiers in Chemistry
- Volume
- 1
- DOI
- https://doi.org/10.3389/fchem.2013.00027
- Publication date
- 10-2013
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/e2a2d5ba-6039-4672-bffd-9288e086d8b5