Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity
- Author(s)
- Sanja Grguric-Sipka, Ivanka Ivanovic, Gordana M. Rakic, Nina M. Todorovic, Nevenka Gligorijevic, Sinisa S. Radulovic, Vladimir Arion, Bernhard Keppler, Zivoslav L. Tesic
- Abstract
Ruthenium(II)-arene complexes of general formulae [(?6-p-cymene)Ru(L1-3)Cl2], where L1-3 is 3-acetylpyridine (1), 4-acetylpyridine (2) and 2-amino-5-chloropyridine (3), correspondingly, [(?6-p-cymene)Ru(HL4,5)Cl2], where HL4 and HL5 are respectively isonicotinic acid (4) and nicotinic acid (5) and [(?6-p-cymene)Ru(HL6-9)Cl], where H2L6-9 represent 2,3-pyridinedicarboxylic acid (6), 2,4-pyridinedicarboxylic acid (7), 2,5-pyridinedicarboxylic acid (8) and 2,6-pyridinedicarboxylic acid (9), were prepared by the reaction of [(?6-p-cymene)2RuCl2]2 (10) with the corresponding ligand in 1:2 molar ratio in isopropanol. The complexes were characterized by elemental analysis, mass spectrometry, IR and NMR spectroscopies. According to these data the molecules adopt the usual "three-leg piano-stool" geometry which is common for this type of complexes. The structures of 1 and 7 were determined by X-ray crystallography. The complexes revealed low antiproliferative activity in six investigated tumor cell lines (HeLa, B16, FemX, MDA-MB-361, MDA-MB-453 and LS-174). The reaction of 6 with 9-methyladenine was studied by 1H NMR, 1H, 1H COSY and 1H, 1H NOESY spectroscopy.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Belgrade, Institute of Oncology and Radiology of Serbia
- Journal
- European Journal of Medicinal Chemistry
- Volume
- 45
- Pages
- 1051-1058
- No. of pages
- 8
- ISSN
- 0223-5234
- DOI
- https://doi.org/10.1016/j.ejmech.2009.11.055
- Publication date
- 2010
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/e4ecb5d4-3510-4c8a-a60d-a7ce7f94f993