Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs
- Author(s)
- Christian G. Hartinger, Michael Größl, Samuel Matthias Meier, Angela Casini, Paul J. Dyson
- Abstract
Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their interactions with biomolecules and potential targets on a molecular level. The exact modes-of-action of these coordination compounds and especially of next generation drug candidates have not been fully elucidated. Due to the fact that DNA is considered a crucial target for platinum chemotherapeutics, metallodrug-DNA binding studies dominated the field for a long time. However, more recently, alternative targets were considered, including enzymes and proteins that may play a role in the overall pharmacological and toxicological profile of metallodrugs. This review focuses on MS-based techniques for studying anticancer metallodrugs in vivo, in vitro and in situ to delineate their modes-of-action.
- Organisation(s)
- Department of Analytical Chemistry, Department of Inorganic Chemistry
- External organisation(s)
- University of Auckland, University of Florence, École polytechnique fédérale de Lausanne
- Journal
- Chemical Society Reviews
- Volume
- 42
- Pages
- 6186-6199
- No. of pages
- 14
- ISSN
- 0306-0012
- DOI
- https://doi.org/10.1039/c3cs35532b
- Publication date
- 2013
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 1030 Physics, Astronomy, 301305 Medical chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/e688b535-5bbd-4f43-b2ff-ae13ad880279