Comparison of three different purification methods for the routine preparation of [11C] metomidate
- Author(s)
- Markus Mitterhauser, Wolfgang Wadsak, Oliver Langer, Jörn Schmaljohann, Georg Zettinig, Robert Dudczak, Helmut Viernstein, Kurt Kletter
- Abstract
PET with (R)-[O-methyl-11C] metomidate ([11C] MTO) is an attractive method for the characterisation of adrenal masses discriminating lesions of adrenal cortical origin from noncortical lesions. [11C] MTO was prepared by the reaction of [11C] methyliodide with the corresponding free acid. Three purification methods have been compared. The method of choice uses preparative HPLC with a ready-to-use weak acidic solvent. © 2003 Elsevier Ltd. All rights reserved.
- Organisation(s)
- Department of Inorganic Chemistry, Department of Nutritional Sciences, Department of Sport and Human Movement Science
- External organisation(s)
- Austrian Research Centers GmbH (ARC Seibersdorf), Rheinische Friedrich-Wilhelms-Universität Bonn
- Journal
- Applied Radiation and Isotopes
- Volume
- 59
- Pages
- 125-128
- No. of pages
- 4
- ISSN
- 0969-8043
- DOI
- https://doi.org/10.1016/S0969-8043(03)00168-4
- Publication date
- 2003
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 3012 Pharmacy, Pharmacology, Toxicology
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/f872f41a-1c48-4144-b494-13bd8853e043