The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions
- Author(s)
- M. P. Sullivan, H. U. Holtkamp, S. M. Meier, C. G. Hartinger
- Abstract
The mode of action of medically relevant coordination and organometallic compounds in a biological environment is crucially dependent on their interactions with biological molecules. Since the discovery of cisplatin, a wide variety of metal complexes have been designed for the treatment of cancer and other diseases as well as for diagnostic purposes. In this chapter, we review the binding events inorganic compounds undergo from administration to the biological target with a special emphasis on the strengths and weaknesses of the methods employed for these studies. We have focused on compounds that are at an advanced preclinical development stage, undergo clinical trials or are in clinical use.
- Organisation(s)
- Department of Analytical Chemistry
- External organisation(s)
- University of Auckland
- Pages
- 355-386
- No. of pages
- 32
- DOI
- https://doi.org/10.1016/B978-0-12-803814-7.00010-1
- Publication date
- 01-2017
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 104002 Analytical chemistry, 301904 Cancer research
- Keywords
- ASJC Scopus subject areas
- General Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/f9d7d90a-d7c1-4d71-9146-3b985ab80878