Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity
- Author(s)
- Jelena Banfic, Anton A. Legin, Michael A. Jakupec, Mathea Sophia Galanski, Bernhard K. Keppler
- Abstract
Ferrocenyl compounds show interesting antiproliferative properties. Consequently, ferrocene bearing moieties were prepared and coupled for the first time to anticancer platinum(IV) complexes. The compounds, featuring either one or two axially coordinated ferrocene-containing ligands, were fully characterized by ESI-MS and multinuclear (
1H,
13C,
15N, and
195Pt) one- and two-dimensional NMR spectroscopy. Their cytotoxicity was investigated in three human cancer cell lines deriving from ovarian carcinoma (CH1), colon carcinoma (SW480), and non-small-cell lung carcinoma (A549) by means of the colorimetric MTT assay. Promising IC
50 values in the low micromolar range in CH1 and SW480 human cancer cells were found.
- Organisation(s)
- Department of Inorganic Chemistry
- Journal
- European Journal of Inorganic Chemistry
- Volume
- 2014
- Pages
- 484-492
- No. of pages
- 9
- ISSN
- 1434-1948
- DOI
- https://doi.org/10.1002/ejic.201301282
- Publication date
- 01-2014
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301305 Medical chemistry
- Keywords
- ASJC Scopus subject areas
- Inorganic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/ff9dc9fb-3eec-40c6-85ff-ffc9eedd77ba