o. Univ.-Prof. Dr. Dr. Bernhard Keppler

Email: bernhard.keppler@univie.ac.at
Phone: +43-1-4277-52602

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Publications


USE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] FOR THE TREATMENT OF CANCER. / Bakewell, Suzanne (Inventor); Sethuraman, Jyothi (Inventor); Keppler, Bernhard (Inventor).
Patent No.: WO2017151762 A1. Sept 08, 2017.

Publications: Patent


Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS. / Pelivan, Karla; Frensemeier, Lisa ; Karst, Uwe et al.
In: The Analyst, Vol. 142, No. 17, 07.09.2017, p. 3165-3176.

Publications: Contribution to journalArticlePeer Reviewed


Impact of the equatorial coordination sphere on the rate of reduction, lipophilicity and cytotoxic activity of platinum(IV) complexes. / Hoefer, Doris; Varbanov, Hristo P.; Hejl, Michaela et al.
In: Journal of Inorganic Biochemistry, Vol. 174, 09.2017, p. 119-129.

Publications: Contribution to journalArticlePeer Reviewed


Distinctly enhanced anticancer activity in vivo by albumin-targeted platinum(IV) prodrugs. / Kowol, Christian; Heffeter, Petra; Mayr, Josef et al.
Book of Abstracts. 2017.

Publications: Contribution to bookContribution to proceedings


Impact of linker modification on the in vitro and in vivo anticancer activity of novel albumin-targeting Platinum (IV) drugs. / Schueffl, H.; Mayr, Josef; Groza, Diana et al.
Book of Abstracts. 2017.

Publications: Contribution to bookContribution to proceedings


On the molecular mechanism of action of organometallic anticancer drugs. / Gerner, Christopher; Meier, Samuel Matthias; Kreutz, Dominique et al.
Book of Abstracts. 2017.

Publications: Contribution to bookContribution to proceedings


Restoring cellular sensitivity to platinum-based drugs by targeted inhibition of STAT3. / Kiakos, Konstantinos; Jakupec, Michael; Valentine, Helen et al.
Book of Abstracts. 2017. p. 76.

Publications: Contribution to bookContribution to proceedings


Ruthenium-based drug interactions with lipid turnover in cancer cells revealed by correlative NanoSIMS and TEM imaging. / Legin, Anton; Schintlmeister, Arno; Eckhard, Margret et al.
Book of Abstracts: Metallomics 2017: The 6th International Symposium on Metallomics, 14. - 17.08.2017, University of Vienna, Vienna, Austria . Wien, 2017. p. 101.

Publications: Contribution to bookContribution to proceedings


Tackling adverse effects in cancer therapy: evaluation of poly(organo)phosphazene-based metallodrug conjugates. / Schönhacker-Alte, Beatrix; Hackl, Carmen; Klose, Matthias et al.
Book of Abstracts. 2017. p. 160.

Publications: Contribution to bookContribution to proceedings


Understanding the pharmacological behavior of the anticancer drug Triapine and its biologically active iron complex. / Pelivan, Karla; Miklos, Walter; Keppler, Bernhard et al.
Book of Abstracts. 2017. p. 76.

Publications: Contribution to bookContribution to proceedings


Oxaliplatin reacts with DMSO only in the presence of water. / Varbanov, Hristo P. (Corresponding author); Ortiz, Daniel; Hoefer, Doris et al.
In: Dalton Transactions, Vol. 46, No. 28, 28.07.2017, p. 8929-8932.

Publications: Contribution to journalArticlePeer Reviewed


Amidoxime platinum(II) complexes: pH-dependent highly selective generation and cytotoxic activity. / Bolotin, Dmitrii S. (Corresponding author); Demakova, Marina Ya.; Legin, Anton A. et al.
In: New Journal of Chemistry, Vol. 41, No. 14, 21.07.2017, p. 6840-6848.

Publications: Contribution to journalArticlePeer Reviewed


DNA or protein? Capillary zone electrophoresismass spectrometry rapidly elucidates metallodrug binding selectivity. / Artner, Christian; Holtkamp, Hannah U. ; Kandioller, Wolfgang et al.
In: Chemical Communications, Vol. 53, No. 57, 21.07.2017, p. 8002-8005.

Publications: Contribution to journalArticlePeer Reviewed


Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue. / Klose, Matthias H. M.; Hejl, Michaela; Heffeter, Petra et al.
In: The Analyst, Vol. 142, No. 13, 07.07.2017, p. 2327-2332.

Publications: Contribution to journalArticlePeer Reviewed


An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin. / Meier, Samuel M. (Corresponding author); Kreutz, Dominique; Winter, Lilli et al.
In: Angewandte Chemie (International Edition), Vol. 56, No. 28, 03.07.2017, p. 8267-8271.

Publications: Contribution to journalArticlePeer Reviewed


Antiproliferative Copper(II) and Platinum(II) Complexes with Bidentate N,N-Donor Ligands. / Sommerfeld, Nadine S.; Guelzow, Jana; Roller, Alexander et al.
In: European Journal of Inorganic Chemistry, Vol. 2017, No. 24, 30.06.2017, p. 3115-3124.

Publications: Contribution to journalArticlePeer Reviewed


Electochemical activation of platinum based cytostatics investigated by means of liquid chromatography and mass spectrometry. / Frensemeier, Lisa ; Köllensperger, Gunda; Kowol, Christian et al.
Book of Abstracts. ed. / Michal Holcapec. 2017.

Publications: Contribution to bookContribution to proceedings


MONOMALEIMIDE-FUNCTIONALIZED PLATINUM COMPOUNDS FOR CANCER THERAPY. / Kowol, Christian (Inventor); Heffeter, Petra (Inventor); Berger, Walter (Inventor) et al.
Patent No.: WO2017097986 A1. Jun 15, 2017.

Publications: Patent


Understanding the metabolism of the anticancer drug Triapine using electrochemistry and liquid chromatography coupled to mass spectrometry (EC/LC/MS). / Pelivan, Karla; Frensemeier, Lisa ; Karst, Uwe et al.
Conference Proceedings . 2017.

Publications: Contribution to bookContribution to proceedings


EGFR-targeting peptide-coupled platinum(IV) complexes. / Mayr, Josef; Hager, Sonja; Koblmueller, Bettina et al.
In: Journal of Biological Inorganic Chemistry, Vol. 22, No. 4, 06.2017, p. 591-603.

Publications: Contribution to journalArticlePeer Reviewed