Publications Institute of Inorganic Chemistry

2022


The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation
Baier, D., Schönhacker-Alte, B., Rusz, M., Pirker, C., Mohr, T., Mendrina, T., Kirchhofer, D., Meier-Menches, S. M., Hohenwallner, K., Schaier, M., Rampler, E., Koellensperger, G., Heffeter, P., Keppler, B. & Berger, W.
Pharmaceutics (2022) 14, 2, 238

The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity
Pósa, V., Hajdu, B., Tóth, G., Dömötor, O., Kowol, C. R., Keppler, B. K., Spengler, G., Gyurcsik, B. & Enyedy, E. A.
Journal of Inorganic Biochemistry (2022) 231, 111786

Metal-mediated C-C bond formation in a platinum(II)-coordinated dipyridylmethane ligand: an unusual example of "ipso-coupling" with solvent involvement
Sommerfeld, N. S., Guelzow, J., Kohl, J. & Grohmann, A.
Zeitschrift für Naturforschung (2022), 77(6)b, 419–423

Comparative Effects of Deferiprone and Salinomycin on Lead-Induced Disturbance in the Homeostasis of Intrarenal Essential Elements in Mice
Gluhcheva, Y., Pashkunova-Martic, I., Schaier, M., Vladov, I., Stoykova, S., Petrova, E., Pavlova, E., Dorkov, P., Helbich, T. H., Keppler, B. & Ivanova, J.
International Journal of Molecular Sciences (2022) 23, 8, 4368

A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance
Fronik, P., Gutmann, M., Vician, P., Stojanovic, M., Kastner, A., Heffeter, P., Pirker, C., Keppler, B. K., Berger, W. & Kowol, C. R.
Communications Chemistry (2022) 5, 1, 46

Solution speciation and human serum protein binding of indium(III) complexes of 8-hydroxyquinoline, deferiprone and maltol
Domotor, O., Keppler, B. K. & Enyedy, E. A.
Journal of Biological Inorganic Chemistry (2022) 27, 3, 315-328

Versatile analytical methodology for evaluation of drug-like properties of potentially multi-targeting anticancer metallodrugs
Foteeva, L. S., Nosova, Y. N., Nazarov, A. A., Keppler, B. K. & Timerbaev, A. R.
Analytical Sciences (2022) 38, 3, 627-632

Systematic Study on the Cytotoxic Potency of Commonly Used Dimeric Metal Precursors in Human Cancer Cell Lines
Geisler, H., Harringer, S., Wenisch, D., Urban, R., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
ChemistryOpen (2022), e202200019

A Proteomic Platform Enables to Test for AML Normalization In Vitro
Meier-Menches, S. M., Neuditschko, B., Janker, L., Gerner, M. C., Schmetterer, K. G., Reichle, A. & Gerner, C.
Frontiers in Chemistry (2022) 10, 826346

Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity
Liszt, K., Wang, Q., Farhadipour, M., Segers, A., Thijs, T., Nys, L., Deleus, E., van der Schueren, B., Gerner, C., Neuditschko, B., Ceulemans, L. J., Lannoo, M., Tack, J. & Depoortere, I.
Journal of Clinical Investigation (2002) 132, 3, 144828

Elemental analysis: an important purity control but prone to manipulations
Kandioller, W., Theiner, J., Keppler, B. K. & Kowol, C. R.
Inorganic Chemistry Frontiers (2022), 9, 412-416

Metal-Organic Cubane Cage with Trimethylplatinum(IV) Vertices
Hendi, Z., Jamali, S., Mahmoudi, S., Samouei, H., Nayeri, S., Chabok, S. M. J. & Jamshidi, Z.
Inorganic Chemistry (2022) 61, 1, 15-19

Metal-Organic Framework superstructures with long-ranged orientational order via E-field assisted liquid crystal assembly
Allahyarli, K., Reithofer, M., Cheng, F., Young, A. J., Kiss, E., Tan, T. T. Y., Prado-Roller, A. & Chin, J. M.
Journal of Colloid and Interface Science (2022), 610, 1027-1034

2021


Water-soluble trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes with bisphosphonate functionalized ligands as anticancer organometallics
Riedl, C. A., Rosner, A., Harringer, S., Salomon, P., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Journal of Inorganic Biochemistry (2021), 225, 111618

Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
Terenzi, A., La Franca, M., van Schoonhoven, S., Panchuk, R., Martinez, A., Heffeter, P., Gober, R., Pirker, C., Vician, P., Kowol, C. R., Stoika, R., Salassa, L., Rohr, J. & Berger, W.
Communications Chemistry (2021) 4, 1, 162

Current and emerging mass spectrometry methods for the preclinical development of metal-based drugs: a critical appraisal
Jarosz, M., Keppler, B. K. & Timerbaev, A. R.
Analytical and Bioanalytical Chemistry (2021)

KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri
Kater, L., Kater, B., Jakupec, M. A., Keppler, B. K. & Prokop, A.
Journal of Biological Inorganic Chemistry (2021) 26, 897-907

Liposomal formulations of anticancer copper(ii) thiosemicarbazone complexes
Mathuber, M., Hager, S., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Dalton Transactions (2021) 50, 16053-16066

Wells-Dawson phosphotungstates as mushroom tyrosinase inhibitors: a speciation study
Lampl, R., Breibeck, J., Gumerova, N., Galanski, M. S. & Rompel, A.
Scientific Reports (2021) 11, 1, 19354

Catalytically Active Gold Nanomaterials Stabilized by N-heterocyclic Carbenes
Eisen, C., Chin, J. M. & Reithofer, M. R.
Chemistry: An Asian Journal (2021) 20, 16, 3026-3037

Effects of N-terminus modified Hx-amides on DNA binding affinity, sequence specificity, cellular uptake, and gene expression
Kiakos, K., Satam, V., Patil, P. C., Sweers, J., Bowerman, M., Tzou, S., Olsen, K., Lee, M., Schaschl, H., Keppler, B. K., Hochhauser, D., Lee, M., Hartley, J. A. & Pett, L.
Bioorganic & Medicinal Chemistry Letters (2021) 47, 128158

Evaporation-Induced Self-Assembly of Small Peptide-Conjugated Silica Nanoparticles
von Baeckmann, C., Rubio, G. M. D. M., Kaehlig, H., Kurzbach, D., Reithofer, M. R. & Kleitz, F.
Angewandte Chemie (International Edition) (2021) 60, 42, 22700-22705

Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo
Schueffl, H., Theiner, S., Hermann, G., Mayr, J., Fronik, P., Groza, D., van Schonhooven, S., Galvez, L., Sommerfeld, N. S., Schintlmeister, A., Reipert, S., Wagner, M., Mader, R. M., Koellensperger, G., Keppler, B. K., Berger, W., Kowol, C. R., Legin, A. & Heffeter, P.
Chemical Science (2021) 38, 12587-12599

Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands
Fronik, P., Poetsch, I., Kastner, A., Mendrina, T., Hager, S., Hohenwallner, K., Schueffl, H., Herndler-Brandstetter, D., Koellensperger, G., Rampler, E., Kopecka, J., Riganti, C., Berger, W., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Journal of Medicinal Chemistry (2021) 64, 16, 12132-12151

Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids
Petrasheuskaya, T. V., Wernitznig, D., Kiss, M. A., May, N. V., Wenisch, D., Keppler, B. K., Frank, E. & Enyedy, E. A.
Journal of Biological Inorganic Chemistry (2021) 26, 775-791

Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer
Herrmann, H. A., Rusz, M., Baier, D., Jakupec, M. A., Keppler, B. K., Berger, W., Koellensperger, G. & Zanghellini, J.
Cancers (2021) 13, 16, 4130

Morpho-metabotyping the oxidative stress response
Rusz, M., Del Favero, G., El Abiead, Y., Gerner, C., Keppler, B. K., Jakupec, M. A. & Koellensperger, G.
Scientific Reports (2021) 11, 1, 15471

Toward a deeper and simpler understanding of serum protein-mediated transformations of magnetic nanoparticles by ICP-MS
Kuznetsova, O., Jarosz, M., Keppler, B. K. & Timerbaev, A. R.
Talanta (2021) 229, 122287

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies
Geisler, H., Westermayr, J., Cseh, K., Wenisch, D., Fuchs, V., Harringer, S., Plutzar, S., Gajic, N., Hejl, M., Jakupec, M. A., Marquetand, P. & Kandioller, W.
Inorganic Chemistry (2021) 60, 13, 9805-9819

Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity
Enyedy, E. A., Petrasheuskaya, T., Kiss, M. A., Wernitznig, D., Wenisch, D., Keppler, B. K., Spengler, G., May, N., Frank, E. & Domotor, O.
Journal of Inorganic Biochemistry (2021) 220, 111468

Multifunctional Pt(iv) prodrug candidates featuring the carboplatin core and deferoxamine
Harringer, S., Hejl, M., Enyedy, E. A., Jakupec, M. A., Galanski, M. S., Keppler, B. K., Dyson, P. J. & Varbanov, H. P.
Dalton Transactions (2021) 50, 8167-8178

Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS
Schweikert, A., Theiner, S., Wernitznig, D., Schoeberl, A., Schaier, M., Neumayer, S., Keppler, B. K. & Koellensperger, G.
Analytical and Bioanalytical Chemistry (2021)

Red Blood Cell Stiffness and Adhesion Are Species-Specific Properties Strongly Affected by Temperature and Medium Changes in Single Cell Force Spectroscopy
Baier, D., Mueller, T., Mohr, T. & Windberger, U.
Molecules (2021) 26, 9, 2771

Mass spectrometry techniques for imaging and detection of metallodrugs
Theiner, S., Schoeberl, A., Schweikert, A., Keppler, B. K. & Koellensperger, G.
Current opinion in chemical biology (2021) 61, 123-134

Development of a cobalt(iii)-based ponatinib prodrug system
Mathuber, M., Gutmann, M., La Franca, M., Vician, P., Laemmerer, A., Moser, P., Keppler, B. K., Berger, W. & Kowol, C. R.
Inorganic Chemistry Frontiers (2021)

Doubly derivatized poly(lactide)-albumin nanoparticles as blood vessel-targeted transport device for magnetic resonance imaging (MRI)
Pashkunova-Martic, I., Kremser, C., Talasz, H., Mistlberger, K., Bechter-Hugl, B., Pfaller, K., Baurecht, D., Debbage, P., Jaschke, W., Helbich, T. H. & Keppler, B.
Journal of Nanoparticle Research (2021) 23, 2, 51

Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum
Neuditschko, B., Legin, A. A., Baier, D., Schintlmeister, A., Reipert, S., Wagner, M., Keppler, B. K., Berger, W., Meier-Menches, S. M. & Gerner, C.
Angewandte Chemie (International Edition) (2021) 60, 10, 5063-5068

2020


First insights into the novel class of organometallic compounds bearing a bidentate selenopyridone coordination motif: Synthesis, characterization, stability and biological investigations
Harringer, S., Matzinger, M., Gajic, N., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Inorganica Chimica Acta (2020) 513, 119919

Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs
Mathuber, M., Schueffl, H., Dömötör, O., Karnthaler, C., Enyedy, É. A., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Inorganic Chemistry (2020)

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation
Enyedy, É. A., May, N. V., Pape, V. F. S., Heffeter, P., Szakács, G., Keppler, B. K. & Kowol, C. R.
Dalton Transactions (2020)

An Organometallic Gold(I) Bis-N-Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells
Meier-Menches, S. M., Neuditschko, B., Zappe, K., Schaier, M., Gerner, M. C., Schmetterer, K. G., Del Favero, G., Bonsignore, R., Cichna-Markl, M., Koellensperger, G., Casini, A. & Gerner, C.
Chemistry: A European Journal (2020) 26, 67, 15528 –15537

Improving the Stability of Maleimide-Thiol Conjugation for Drug Targeting
Lahnsteiner, M., Kastner, A., Mayr, J., Roller, A., Keppler, B. K. & Kowol, C. R.
Chemistry: A European Journal (2020)

Ameliorative effects of deferiprone and tetraethylammonium salt of salinomycinic acid on lead-induced toxicity in mouse testes
Pavlova, E., Pashkunova-Martic, I., Schaier, M., Petrova, E., Gluhcheva, Y., Dorkov, P., Helbich, T. H., Keppler, B., Koellensperger, G. & Ivanova, J.
Environmental Science and Pollution Research (2020)

1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity
Recnik, L-M., Kandioller, W. & Mindt, T. L.
Molecules (2020) 25, 16, 3576

I-124 Radiolabeling of a Au-III-NHC Complex for In Vivo Biodistribution Studies
Guarra, F., Terenzi, A., Pirker, C., Passannante, R., Baier, D., Zangrando, E., Gomez-Vallejo, V., Biver, T., Gabbiani, C., Berger, W., Llop, J. & Salassa, L.
Angewandte Chemie (International Edition) (2020) 132, 39, 17278-17284

Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux
Bormio Nunes, J. H., Hager, S., Mathuber, M., Pósa, V., Roller, A., Enyedy, É. A., Stefanelli, A., Berger, W., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Journal of Medicinal Chemistry (2020) 63, 22, 13719-13732

High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones
Hager, S., Pape, V. F. S., Posa, V., Montsch, B., Uhlik, L., Szakacs, G., Toth, S., Jabronka, N., Keppler, B. K., Kowol, C. R., Enyedy, E. A. & Heffeter, P.
Antioxidants and Redox Signaling (2020), 395-414

How versatile is the use of ultrafiltration to study biointeractions of therapeutic metallodrugs?
Foteeva, L. S., Kuznetsova, O. & Keppler, B. K.
Analytical Biochemistry (2020) 598, 113697

Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib
Bielec, B., Schueffl, H., Terenzi, A., Berger, W., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Bioorganic Chemistry (2020) 99, 103778

Fast and Highly Efficient Affinity Enrichment of Azide-A-DSBSO Cross-Linked Peptides
Matzinger, M., Kandioller, W., Doppler, P., Heiss, E. H. & Mechtler, K.
Journal of Proteome Research (2020) 19, 5, 2071-2079

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior
Harringer, S., Happl, B., Ozenil, M., Kast, C., Hejl, M., Wernitznig, D., Legin, A. A., Schweikert, A., Gajic, N., Roller, A., Koellensperger, G., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Chemistry: A European Journal (2020) 26, 24, 5419-5433

Investigations on the Anticancer Potential of Benzothiazole-Based Metallacycles
Mokesch, S., Cseh, K., Geisler, H., Hejl, M., Klose, M. H. M., Roller, A., Meier-Menches, S. M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Frontiers in Chemistry (2020) 8, 209

STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
Oberhuber, M., Pecoraro, M., Rusz, M., Oberhuber, G., Wieselberg, M., Haslinger, P., Gurnhofer, E., Schlederer, M., Limberger, T., Lagger, S., Pencik, J., Kodajova, P., Hoegler, S., Stockmaier, G., Grund-Groeschke, S., Aberger, F., Bolis, M., Theurillat, J-P., Wiebringhaus, R., Weiss, T., Haitel, A., Brehme, M., Wadsak, W., Griss, J., Mohr, T., Hofer, A., Jaeger, A., Pollheimer, J., Egger, G., Koellensperger, G., Mann, M., Hantusch, B. & Kenner, L.
Molecular Systems Biology (2020) 16, 4, 9247

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase II alpha inhibitors
Legina, M. S., Nogueira, J. J., Kandioller, W., Jakupec, M. A., Gonzalez, L. & Keppler, B. K.
Journal of Biological Inorganic Chemistry (2020), 451-465

Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib
Englinger, B., Laemmerer, A., Moser, P., Kallus, S., Roehrl, C., Pirker, C., Baier, D., Mohr, T., Niederstaetter, L., Meier-Menches, S. M., Gerner, C., Gabler, L., Gojo, J., Timelthaler, G., Senkiv, J., Jaeger, W., Kowol, C. R., Heffeter, P. & Berger, W.
International Journal of Cancer (2020)

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb-III}(4)(A-alpha-XW9O34)(2)](n-) (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity
Ma, T., Yang, P., Dammann, I., Lin, Z., Mougharbel, A. S., Li, M-X., Adasalitei, F., Mitea, R., Silvestru, C., Thorstenson, C., Ullrich, M. S., Cseh, K., Jakupec, M. A., Keppler, B. K., Donalisio, M., Cavalli, R., Lembo, D. & Kortz, U.
Inorganic Chemistry (2020) 59, 2978-2987

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib
Bielec, B., Poetsch, I., Ahmed, E., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Molecules (2020) 25, 5

The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts
Neuditschko, B., Janker, L., Niederstaetter, L., Brunmair, J., Krivanek, K., Izraely, S., Sagi-Assif, O., Meshel, T., Keppler, B. K., Del Favero, G., Witz, I. P. & Gerner, C.
Molecular and Cellular Proteomics (2020) 19, 3, 478-489

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behavior
Geisler, H., Wernitznig, D., Hejl, M., Gajic, N., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (2020) 49, 5, 1393-1397

Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations
Meszaros, J. P., Geisler, H., Poljarevic, J. M., Roller, A., Legina, M. S., Hejl, M., Jakupec, M. A., Keppler, B. K., Kandioller, W. & Enyedy, E. A.
Journal of Organometallic Chemistry (2020) 907, 121070

2019


Synthesis and Cytotoxicity of Water-Soluble Dual- and Triple-Action Satraplatin Derivatives: Replacement of Equatorial Chlorides of Satraplatin by Acetates
Karmakar, S., Poetsch, I., Kowol, C. R., Heffeter, P. & Gibson, D.
Inorganic Chemistry (2019) 58, 24, 16676-16688

Chemical imaging and assessment of cadmium distribution in the human body
Egger, A. E., Grabmann, G., Gollmann-Tepekoeylue, C., Pechriggl, E. J., Artner, C., Tuerkcan, A., Hartinger, C. G., Fritsch, H., Keppler, B. K., Brenner, E., Grimm, M., Messner, B. & Bernhard, D.
Metallomics (2019) 11, 12, 2010-2019

Single spheroid metabolomics: Optimizing sample preparation of three-dimensional multicellular tumor spheroids
Rusz, M., Rampler, E., Keppler, B. K., Jakupec, M. A. & Köllensperger, G.
Metabolites (2019) 9, 12, 304

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo-A Comparison of O,O-, S,O-, and N,N-Chelate Effects
Berasaluce, I., Cseh, K., Roller, A., Hejl, M., Heffeter, P., Berger, W., Jakupec, M. A., Kandioller, W., Malarek, M. S. & Keppler, B. K.
Chemistry: A European Journal (2019)

Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics
Galvez, L., Rusz, M., Schwaiger-Haber, M., El Abiead, Y., Hermann, G., Jungwirth, U., Berger, W., Keppler, B. K., Jakupec, M. A. & Köllensperger, G.
Metallomics (2019) 11, 10, 1716-1728

Targeting G-quadruplexes with Organic Dyes: Chelerythrine-DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy
Terenzi, A., Gattuso, H., Spinello, A., Keppler, B. K., Chipot, C., Dehez, F., Barone, G. & Monari, A.
Antioxidants (2019) 8, 10, 472

pH responsive histidin-2-ylidene stabilized gold nanoparticles
Young, A. J., Eisen, C., Rubio, G. M. D. M., Chin, J. M. & Reithofer
Journal of Inorganic Biochemistry (2019) 199, 110707

An improved protocol for ICP-MS-based assessment of the cellular uptake of metal-based nanoparticles
Kruszewska, J., Kur, A., Kulpinska, D., Grabowska-Jadach, I., Matczuk, M., Keppler, B. K., Timerbaev, A. R. & Jarosz, M.
Journal of Pharmaceutical and Biomedical Analysis (2019) 174, 300-304

Ruthenium arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition
Hager, L. A., Mokesch, S., Kieler, C., Alonso-de Castro, S., Baier, D., Roller, A., Kandioller, W., Keppler, B. K., Berger, W., Salassa, L. & Terenzi, A.
Dalton Transactions (2019) 48, 32, 12040-12049

Dynamic Electric Field Alignment of Metal-Organic Framework Microrods
Cheng, F., Young, A. J., Bouillard, J-S. G., Kemp, N. T., Guillet-Nicolas, R., Hall, C. H., Roberts, D., Jaafar, A. H., Adawi, A. M., Kleitz, F., Imhof, A., Reithofer, M. R. & Chin, J. M.
Journal of the American Chemical Society (2019) 141, 33, 12989-12993

Interplay of Three G-Quadruplex Units in the KIT Promoter
Ducani, C., Bernardinelli, G., Hogberg, B., Keppler, B. K. & Terenzi, A.
Journal of the American Chemical Society (2019) 141, 26, 10205-10213

Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group
Mokesch, S., Schwarz, D., Hejl, M., Klose, M. H. M., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Molecules (2019) 24, 13, 2373

Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal Pt-II Metallacycle
Domarco, O., Kieler, C., Pirker, C., Dinhof, C., Englinger, B., Reisecker, J. M., Timelthaler, G., Garcia, M. D., Peinador, C., Keppler, B. K., Berger, W. & Terenzi, A.
Angewandte Chemie (International Edition) (2019) 58, 24, 8007-8012

First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro
Wernitznig, D., Kiakos, K., Del Favero, G., Harrer, N., Machat, H., Osswald, A., Jakupec, M. A., Wernitznig, A., Sommergruber, W. & Keppler, B. K.
Metallomics (2019) 11, 6, 1044-1048

Heart-cut 2DSEC-RP-LC-ICP-MS as a screening tool in metal-based anticancer research
Galvez, L., Rusz, M., Jakupec, M. A. & Koellensperger, G.
Journal of Analytical Atomic Spectrometry (2019) 34, 6, 1279-1286

Synthesis, characterization, lipophilicity and cytotoxic properties of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes
Hizal, S., Hejl, M., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Inorganica Chimica Acta (2019) 491, 76-83

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt-IV Complexes under Physiological Conditions
Kastner, A., Poetsch, I., Mayr, J., Burda, J. V., Roller, A., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Angewandte Chemie (International Edition) (2019) 58, 22, 7464-7469

One-step synthesis and XPS investigations of chiral NHC-Au(0)/Au(i) nanoparticles
Young, A. J., Sauer, M., Rubio, G. M. D. M., Sato, A., Foelske, A., Serpell, C. J., Chin, J. M. & Reithofer, M. R.
Nanoscale (2019) 11, 17, 8327-8333

A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum
Kuznetsova, O., Reshetnikova, I. S., Shtykov, S. N., Karandashev, V. K., Keppler, B. K. & Timerbaev, A. R.
Chemical Communications (2019) 55, 29, 4270-4272

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis
Groza, D., Gehrig, S., Dinhof, C., Holcman, M., Pirker, C., Schueffl, H., Ogris, M., Lubitz, W., Keppler, B., Pashkunova-Martic, I., Kowol, C., Berger, W. & Heffeter, P.
European Journal of Cancer (2019) 110, S1, S23-S24

Mini-review: Targeted radiopharmaceuticals incorporating reversible, low molecular weight albumin binders
Brandt, M., Cardinale, J., Giammei, C., Guarrochena, X., Happl, B., Jouini, N. & Mindt, T. L.
Nuclear Medicine and Biology (2019) 70, 46-52

Synthesis, Characterization, Cytotoxicity, and Time-Dependent NMR Spectroscopic Studies of (SP-4-3)-Oxalato[(1R,2R,4R/1S,2S,4S)-(4-trifluoromethyl-cyclohexane-1,2-diamine)]platinum(II)
Hizal, S., Hejl, M., Jungmann, C., Jakupec, M. A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2019) 6, 856-864

Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K. & Berger, W.
Chemical Reviews (2019) 119, 2, 1519-1624

Synthesis, characterization, cytotoxic activity, and 19F NMR spectroscopic investigations of (OC-6-33)-diacetato(ethane-1,2-diamine)bis(3,3,3-trifluoropropanoato)platinum(IV) and its platinum(II) counterpart
Hoefer, D., Cseh, K., Hejl, M., Roller, A., Jakupec, M. A., Galanski, M. & Keppler, B. K.,
Inorganica Chimica Acta (2019) 490, 190-199

Coordination chemistry of S-substituted isothiosemicarbazides and isothiosemicarbazones
Arion, V.
Coordination Chemistry Reviews (2019) 387, 348-397

Analytical methodology for studying cellular uptake, processing and localization of gold nanoparticles
Matczuk, M., Ruzik, L., Aleksenko, S. S., Keppler, B. K., Jarosz, M. & Timerbaev, A. R.
Analytica Chimica Acta (2019) 1052, 1-9

Keggin-type polyoxotungstates as mushroom tyrosinase inhibitors - A speciation study
Breibeck, J., Gumerova, N. I., Boesen, B. B., Galanski, M. & Rompel, A.
Scientific Reports (2019) 9, 12, 5183

Direct ink writing of catalytically active UiO-66 polymer composites
Young, A. J., Guillet-Nicolas, R., Marshall, E. S., Kleitz, F., Goodhand, A. J., Glanville, L. B. L., Reithofer, M. R. & Chin, J. M.
Chemical Communications (2019) 55, 15, 2190-2193

Synthesis, Characterization, Cytotoxicity, and Time-Dependent NMR Spectroscopic Studies of (SP-4-3)-Oxalato[(1R,2R,4R/1S,2S,4S)-(4-trifluoromethyl-cyclohexane-1,2-diamine)]platinum(II)
Hizal, S., Hejl, M., Jungmann, C., Jakupec, M. A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2019) 6, 856-864

New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action
Ohui, K., Afanasenko, E., Bacher, F., Ting, R. L. X., Zafar, A., Blanco-Cabra, N., Torrents, E., Domotor, O., May, N. V., Darvasiova, D., Enyedy, E. A., Popovic-Bijelic, A., Reynisson, J., Rapta, P., Babak, M. V., Pastorin, G. & Arion, V. B.
Journal of Medicinal Chemistry (2019), 62, 2, 512-530

Stereolithographic 3D printing of extrinsically self-healing composites
Sanders, P., Young, A. J., Qin, Y., Fancey, K. S., Reithofer, M. R., Guillet-Nicolas, R., Kleitz, F., Pamme, N. & Chin, J. M.
Scientific Reports (2019) 9, 388

Investigation of the cytotoxic potential of methyl imidazole-derived thiosemicarbazones and their copper(II) complexes with dichloroacetate as a co-ligand
Palamarciuc, O., Milunovic, M. N. M., Sirbu, A., Stratulat, E., Pui, A., Gligorijevic, N., Radulovic, S., Kozisek, J., Darvasiova, D., Rapta, P., Enyedy, E. A., Novitchi, G., Shova, S. & Arion, V. B.
New Journal of Chemistry (2019) 43, 3, 1340-1357

Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes
Kallus, S., Uhlik, L., van Schoonhoven, S., Pelivan, K., Berger, W., Enyedy, E. A., Hofmann, T., Heffeter, P., Kowol, C. R. & Keppler, B. K.
Journal of Inorganic Biochemistry (2019) 190, 85-97

Synthesis, Characterization and in vitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib
Karnthaler-Benbakka, C., Koblmueller, B., Mathuber, M., Holste, K., Berger, W., Heffeter, P., Kowol, C. R. & Keppler, B. K.
Chemistry & Biodiversity (2019) 16, 1, 1800520

2018


Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074
Englinger, B., Kallus, S., Senkiv, J., Laemmerer, A., Moser, P., Gabler, L., Groza, D., Kowol, C. R., Heffeter, P., Grusch, M. & Berger, W.
Fuel Cells (2018) 7, 12, 259

Biological activity of Pt-IV prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis
Alonso-de Castro, S., Terenzi, A., Hager, S., Englinger, B., Faraone, A., Calvo Martinez, J., Galanski, M., Keppler, B. K., Berger, W. & Salassa, L.
Scientific Reports (2018) 8, 17198

New Variations on the Theme of Gold(III) C boolean AND N boolean AND N Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization
Carboni, S., Zucca, A., Stoccoro, S., Maiore, L., Arca, M., Ortu, F., Artner, C., Keppler, B. K., Meier-Menches, S. M., Casini, A. & Cinellu, M. A.
Inorganic Chemistry (2018) 57, 23, 14852-14865

Biological activity of Pt-IV prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis
Alonso-de Castro, S., Terenzi, A., Hager, S., Englinger, B., Faraone, A., Calvo Martinez, J., Galanski, M., Keppler, B. K., Berger, W. & Salassa, L.
Scientific Reports (2018) 8, 17198

The Impact of Leaving Group Variation on the Anticancer Activity of Molybdenocenes
Kandioller, W., Reikersdorfer, M., Theiner, S., Roller, A., Hejl, M., Jakupec, M. A., Malarek, M. S. & Keppler, B. K.
Organometallics (2018) 37, 21, 3909-3916

Critical assessment of different methods for quantitative measurement of metallodrug-protein associations
Galvez, L., Theiner, S., Grabarics, M., Kowol, C. R., Keppler, B. K., Hann, S. & Koellensperger, G.,
Analytical and Bioanalytical Chemistry (2018) 410, 27, 7211-7220

Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index
Kallus, S., Englinger, B., Senkiv, J., Laemmerer, A., Heffeter, P., Berger, W., Kowol, C. R. & Keppler, B. K.
Nanomedicine: Nanotechnology Biology and Medicine (2018) 14, 8, 2632-2643

The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition
Hager, S., Korbula, K., Bielec, B., Grusch, M., Pirker, C., Schosserer, M., Liendl, L., Lang, M., Grillari, J., Nowikoysky, K., Pape, V. F. S., Mohr, T., Szakacs, G., Keppler, B. K., Berger, W., Kowol, C. R. & Heffeter, P.
Cell Death & Disease (2018) 9, 1052

Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS
Klose, M. H. M., Schöberl, A., Heffeter, P., Berger, W., Hartinger, C. G., Koellensperger, G., Meier-Menches, S. M. & Keppler, B. K.
Monatshefte für Chemie (2018) 149, 10, 1719-1726

Understanding the interactions of diruthenium anticancer agents with amino acids
Nazarov, A. A., Mendoza Parra Ferri, M. G., Hanif, M., Keppler, B. K., Dyson, P. J. & Hartinger, C. G.
Journal of Biological Inorganic Chemistry (2018) 23, 7, 1159-1164

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction
Streciwilk, W., Terenzi, A., Cheng, X., Hager, L., Dabiri, Y., Prochnow, P., Bandow, J. E., Woelfl, S., Keppler, B. K. & Ott, I.
European Journal of Medicinal Chemistry (2018), 156, 148-161

Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis-1,8-naphthalimide Ligands
Streciwilk, W., Terenzi, A., Lo Nardo, F., Prochnow, P., Bandow, J. E., Keppler, B. K. & Ott, I.
European Journal of Inorganic Chemistry (2018) 26, 3104-3112

Structural and solution equilibrium studies on half-sandwich organorhodium complexes of (N,N) donor bidentate ligands
Meszaros, J. P., Domotor, O., Hackl, C. M., Roller, A., Keppler, B. K., Kandioller, W. & Enyedy, E. A.
New Journal of Chemistry (2018) 42, 13, 11174-11184

REVIEW: metal complexes as urease inhibitors
Habala, L., Devinsky, F. & Egger, A. E.
Journal of Coordination Chemistry (2018) 71, 7, 907-940

Comparative studies on the human serum albumin binding of the clinically approved EGFR inhibitors gefitinib, erlotinib, afatinib, osimertinib and the investigational inhibitor KP2187
Domotor, O., Pelivan, K., Borics, A., Keppler, B. K., Kowol, C. R. & Enyedy, E. A.
Journal of Pharmaceutical and Biomedical Analysis (2018) 154, 321-331

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)
Frensemeier, L. M., Mayr, J., Koellensperger, G., Keppler, B. K., Kowol, C. R. & Karst, U.
The Analyst (2018) 143, 9, 1997-2001

Design, synthesis, nuclear localization, and biological activity of a fluorescent duocarmycin analog, HxTfA
Kiakos, K., Englinger, B., Yanow, S. K., Wernitznig, D., Jakupec, M. A., Berger, W., Keppler, B. K., Hartley, J. A., Lee, M. & Patil, P. C.
Bioorganic & Medicinal Chemistry Letters (2018) 28, 8, 1342-1347

The impact of whole human blood on the kinetic inertness of platinum(IV) prodrugs - an HPLC-ICP-MS study
Theiner, S., Grabarics, M., Galvez, L., Varbanov, H. P., Sommerfeld, N. S., Galanski, M., Keppler, B. K. & Koellensperger
Dalton Transactions (Print Edition) (2018) 47, 15, 5252-5258

N- and S-donor leaving groups in triazole-based ruthena(II) cycles: potent anticancer activity, selective activation, and mode of action studies
Riedl, C. A., Hejl, M., Klose, M. H. M., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (Print Edition) (2018) 47, 13, 4625-4638

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action
Babak, M. V., Pfaffeneder-Kmen, M., Meier-Menches, S. M., Legina, M. S., Theiner, S., Licona, C., Orvain, C., Hejl, M., Hanif, M., Jakupec, M. A., Keppler, B. K., Gaiddon, C. & Hartinger, C. G.
Inorganic Chemistry (2018) 57, 5, 2851-2864

A comparative study of alpha-N-pyridyl thiosemicarbazones: Spectroscopic properties, solution stability and copper(II) complexation
Domotor, O., May, N. V., Pelivan, K., Kiss, T., Keppler, B. K., Kowol, C. R. & Enyedy, E. A.
Inorganica Chimica Acta (2018) 472, 264-275

Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS
Klose, M. H. M., Theiner, S., Kornauth, C., Meier-Menches, S. M., Heffeter, P., Berger, W., Koellensperger, G. & Keppler, B. K.
Metallomics (2018) 10, 3, 388-396

Complexes of pyridoxal thiosemicarbazones formed with vanadium(IV/V) and copper(II): Solution equilibrium and structure
Jakusch, T., Kozma, K., Enyedy, E. A., May, N. V., Roller, A., Kowol, C. R., Keppler, B. K. & Kiss, T.
Inorganica Chimica Acta (2018) 472, 243-253

Comparison of metabolic pathways of different alpha-N-heterocyclic thiosemicarbazones
Pelivan, K., Frensemeier, L. M., Karst, U., Koellensperger, G., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Analytical and Bioanalytical Chemistry (2018) 410, 9, 2343-2361

Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development
Heffeter, P., Pape, V. F. S., Enyedy, E. A., Keppler, B. K., Szakacs, G. & Kowol, C. R.
Antioxidants and Redox Signaling (2018)

Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development
Meier-Menches, S. M., Gerner, C., Berger, W., Hartinger, C. G. & Keppler, B. K.
Chemical Society Reviews (2018) 47, 3, 909-928

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis
Groza, D., Gehrig, S., Kudela, P., Holcmann, M., Pirker, C., Dinhof, C., Schueffl, H. H., Sramko, M., Hoebart, J., Alioglu, F., Grusch, M., Ogris, M., Lubitz, W., Keppler, B. K., Pashkunova-Martic, I., Kowol, C. R., Sibilia, M., Berger, W. & Heffeter, P.
OncoImmunology (2018) 7, 5, 1424676

Studies of KP46 and KP1019 and the Hydrolysis Product of KP1019 in Lipiodol Emulsions: Preparation and Initial Characterizations as Potential Theragnostic Agents
Pashkunova-Martic, I., Cebrian Losantos, B., Kandler, N. & Keppler, B. Current Drug Delivery (2018) 15, 1, 134 - 142

2017


Fast High-Resolution Laser Ablation-Inductively Coupled Plasma Mass Spectrometry Imaging of the Distribution of Platinum-Based Anticancer Compounds in Multicellular Tumor Spheroids
Theiner, S., Van Malderen, S. J. M., Van Acker, T., Legin, A., Keppler, B. K., Vanhaecke, F. & Koellensperger
Analytical Chemistry (2017) 89, 23, 12641-12645

A fluorescent oxaliplatin derivative for investigation of oxaliplatin resistance using imaging techniques
Kalayda, G. V., Kullmann, M., Galanski, M. & Gollos
Journal of Biological Inorganic Chemistry (2017) 22, 8, 1295-1304

Comparative equilibrium and structural studies of new pentamethylcyclopentadienyl rhodium complexes bearing (O, N) donor bidentate ligands
Domotor, O., Hackl, C. M., Bali, K., Roller, A., Hejl, M., Jakupec, M. A., Keppler, B. K., Kandioller, W. & Enyedy, E. A.
Journal of Organometallic Chemistry (2017) 846, 287-295

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis
Schoenhacker-Alte, B., Mohr, T., Pirker, C., Kryeziu, K., Kuhn, P-S., Buck, A., Hofmann, T., Gerner, C., Hermann, G., Koellensperger, G., Keppler, B. K., Berger, W. & Heffeter, P.
Cancer Letters (2017) 404, 79-88

Synthesis and in vivo anticancer evaluation of poly(organo) phosphazene-based metallodrug conjugates
Hackl, C. M., Schoenhacker-Alte, B., Klose, M. H. M., Henke, H., Legina, M. S., Jakupec, M. A., Berger, W., Keppler, B. K., Brueggemann, O., Teasdale, I., Heffeter, P. & Kandioller, W.
Dalton Transactions (Print Edition) (2017) 46, 36, 12114-12124

Magnetic Control of MOF Crystal Orientation and Alignment
Cheng, F., Marshall, E. S., Young, A. J., Robinson, P. J., Bouillard, J-S. G., Adawi, A. M., Vermeulen, N. A., Farha, O. K., Reithofer, M. R. & Chin, J. M.
Chemistry: A European Journal (2017) 23, 62, 15578-15582

Optically active histidin-2-ylidene stabilised gold nanoparticles
Young, A. J., Serpell, C. J., Chin, J. M. & Reithofer, M. R.
Chemical Communications  (2017) 53, 92, 12426-12429

Platinum(IV) Complexes Featuring Axial Michael Acceptor Ligands - Synthesis, Characterization, and Cytotoxicity
Sommerfeld, N. S., Strohhofer, D., Cseh, K., Theiner, S., Jakupec, M. A., Koellensperger, G., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2017) 34, 4049-4054

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
Englinger, B., Kallus, S., Senkiv, J., Heilos, D., Gabler, L., Van Schoonhoven, S., Terenzi, A., Moser, P., Pirker, C., Timelthaler, G., Jaeger, W., Kowol, C. R., Heffeter, P., Grusch, M. & Berger, W.
Journal of Experimental and Clinical Cancer Research  (2017) 36, 122

Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS
Pelivan, K., Frensemeier, L., Karst, U., Koellensperger, G., Bielec, B., Hager, S., Heffeter, P., Keppler, B. K. & Kowol, C. R.
The Analyst (2017) 142, 17, 3165-3176

Optically active histidin-2-ylidene stabilised gold nanoparticles
Young, A. J., Serpell, C. J., Chin, J. M. & Reithofer, M. R.
Chemical Communications  (2017) 53, 92, 12426-12429

Magnetic Control of MOF Crystal Orientation and Alignment
Cheng, F., Marshall, E. S., Young, A. J., Robinson, P. J., Bouillard, J-S. G., Adawi, A. M., Vermeulen, N. A., Farha, O. K., Reithofer, M. R. & Chin, J. M.
Chemistry: A European Journal (2017) 23, 62, 15578-15582

Impact of the equatorial coordination sphere on the rate of reduction, lipophilicity and cytotoxic activity of platinum(IV) complexes
Hoefer, D., Varbanov, H. P., Hejl, M., Jakupec, M. A., Roller, A., Galanski, M. & Keppler, B. K.
Journal of Inorganic Biochemistry (2017) 174, 119-129

Multifunctional alpha(v)beta(6) Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting
Conibear, A. C., Hager, S., Mayr, J., Klose, M. H. M., Keppler, B. K., Kowol, C. R., Heffeter, P. & Becker, C. F. W.
Bioconjugate Chemistry (2017) 28, 9, 2429-2439

Self-Ordering Secondary Structure of D- and L-Arginine-Derived Polyamidoamino Acids
Manfredi, A., Mauro, N., Terenzi, A., Alongi, J., Lazzari, F., Ganazzoli, F., Raffaini, G., Ranucci, E. & Ferruti, P.
ACS Macro Letters (2017) 6, 9, 987-991

Oxaliplatin reacts with DMSO only in the presence of water
Varbanov, H. P., Ortiz, D., Hoefer, D., Menin, L., Galanski, M., Keppler, B. K. & Dyson, P. J.
Dalton Transactions (Print Edition)
(2017) 46, 28, 8929-8932

Amidoxime platinum(II) complexes: pH-dependent highly selective generation and cytotoxic activity
Bolotin, D. S., Demakova, M. Y., Legin, A. A., Suslonov, V. V., Nazarov, A. A., Jakupec, M. A., Keppler, B. K. & Kukushkin, V. Y.
New Journal of Chemistry
(2017) 41, 14, 6840-6848

DNA or protein? Capillary zone electrophoresismass spectrometry rapidly elucidates metallodrug binding selectivity
Artner, C., Holtkamp, H. U., Kandioller, W., Hartinger, C. G., Meier, S. M. & Keppler, B. K. 2
Chemical Communications
(2017) 53, 57, 8002-8005

Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue
Klose, M. H. M., Hejl, M., Heffeter, P., Jakupec, M. A., Meier, S. M., Berger, W. & Keppler, B. K.
The Analyst
(2017) 142, 13, 2327-2332

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin
Meier, S. M., Kreutz, D., Winter, L., Klose, M. H. M., Cseh, K., Weiss, T., Bileck, A., Alte, B., Mader, J. C., Jana, S., Chatterjee, A., Bhattacharyya, A., Hejl, M., Jakupec, M. A., Heffeter, P., Berger, W., Hartinger, C. G., Keppler, B. K., Wiche, G. & Gerner, C.
Angewandte Chemie (International Edition) (2017) 56, 28, 8267-8271

Antiproliferative Copper(II) and Platinum(II) Complexes with Bidentate N,N-Donor Ligands
Sommerfeld, N. S., Guelzow, J., Roller, A., Cseh, K., Jakupec, M. A., Grohmann, A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry
(2017) 24, 3115-3124

EGFR-targeting peptide-coupled platinum(IV) complexes
Mayr, J., Hager, S., Koblmueller, B., Klose, M. H. M., Holste, K., Fischer, B., Pelivan, K., Berger, W., Heffeter, P., Kowol, C. R. & Keppler, B. K.
Journal of Biological Inorganic Chemistry
(2017) 22, 4, 591-603

Functionalization of Ruthenium(II)(eta(6)-p-cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies
Hanif, M., Meier, S. M., Adhireksan, Z., Henke, H., Martic, S., Movassaghi, S., Labib, M., Kandioller, W., Jamieson, S. M. F., Hejl, M., Jakupec, M. A., Kraatz, H-B., Davey, C. A., Keppler, B. K. & Hartinger, C. G.
Chempluschem
(2017) 82, 6, 841-847

Synthesis, Characterization, and Time-Dependent NMR Spectroscopy Studies of (SP-4-2)-[(trans-1R,2R/1S,2S-N-15(2))-Cyclohexane-1,2-diamine][(C-13(2))oxalato]platinum(II)
Hoefer, D., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry
(2017) 17, 2347-2354

Rapid generation of hydrogen peroxide contributes to the complex cell death induction by the angucycline antibiotic landomycin E
Panchuk, R. R., Lehka, L. V., Terenzi, A., Matselyukh, B. P., Rohr, J., Jha, A. K., Downey, T., Kril, I. J., Herbacek, I., Schoonhoven, S., Heffeter, P., Stoika, R. S. & Berger, W.
Free Radical Biology & Medicine
(2017) 106, 134-147

Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition
Kubista, B., Schoefl, T., Mayr, L., van Schoonhoven, S., Heffeter, P., Windhager, R., Keppler, B. K. & Berger, W.
Journal of Experimental and Clinical Cancer Research
(2017) 36, 52

Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research
Lee, R. F. S., Theiner, S., Meibom, A., Koellensperger, G., Keppler, B. K. & Dyson, P. J.
Metallomics
(2017) 9, 4, 365-381

Enhancing the Cytotoxic Activity of Anticancer Pt-IV Complexes by Introduction of Lonidamine as an Axial Ligand
Nosova, Y. N., Foteeva, L. S., Zenin, I. V., Fetisov, T. I., Kirsanov, K. I., Yakubovskaya, M. G., Antonenko, T. A., Tafeenko, V. A., Aslanov, L. A., Lobas, A. A., Gorshkov, M. V., Galanski, M., Keppler, B. K., Timerbaev, A. R., Milaeva, E. R. & Nazarov, A. A.
European Journal of Inorganic Chemistry
(2017) 12, 1785-1791

Low-Generation Polyamidoamine Dendrimers as Drug Carriers for Platinum(IV) Complexes
Sommerfeld, N. S., Hejl, M., Klose, M. H. M., Schreiber-Brynzak, E., Bileck, A., Meier, S. M., Gerner, C., Jakupec, M. A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry
(2017) 12, 1713-1720

{Ru(CO)(x)}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo
Tamasi, G., Merlino, A., Scaletti, F., Heffeter, P., Legin, A. A., Jakupec, M. A., Berger, W., Messori, L., Keppler, B. K. & Cini, R.
Dalton Transactions (Print Edition)
(2017) 46, 9, 3025-3040

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo
Mayr, J., Heffeter, P., Groza, D., Galvez, L., Koellensperger, G., Roller, A., Alte, B., Haider, M., Berger, W., Kowol, C. R. & Keppler, B. K.
Chemical Science
(2017) 8, 3, 2241-2250

Task-specific thioglycolate ionic liquids for heavy metal extraction: Synthesis, extraction efficacies and recycling properties
Platzer, S., Kar, M., Leyma, R., Chib, S., Roller, A., Jirsa, F., Krachler, R., MacFarlane, D. R., Kandioller, W. & Keppler, B. K.
Journal of Hazardous Materials (2017) 324, Part B, 241-249

Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance
Englinger, B., Mair, M., Miklos, W., Pirker, C., Mohr, T., van Schoonhoven, S., Loetsch, D., Körner, W., Ferk, F., Knasmueller, S., Heffeter, P., Keppler, B. K., Grusch, M. & Berger, W.
British Journal of Cancer
(2017) 116, 4, 489-500

Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents
Streciwilk, W., Terenzi, A., Misgeld, R., Frias, C., Jones, P. G., Prokop, A., Keppler, B. K. & Ott, I.
ChemMedChem
(2017) 12, 3, 214-225

Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse
Blazevic, A., Hummer, A. A., Heffeter, P., Berger, W., Filipits, M., Cibin, G., Keppler, B. K. & Rompel, A.
Scientific Reports
(2017) 7, 40966

Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates
Riedl, C. A., Flocke, L. S., Hejl, M., Roller, A., Klose, M. H. M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Inorganic Chemistry
(2017) 56, 1, 528-541

Comparative studies of oxaliplatin-based platinum(IV) complexes in different in vitro and in vivo tumor models
Goeschl, S., Schreiber-Brynzak, E., Pichler, V., Cseh, K., Heffeter, P., Jungwirth, U., Jakupec, M. A., Berger, W. & Keppler, B. K.
Metallomics
(2017) 9, 3, 309-322

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin
Nosova, Y. N., Zenin, I. V., Maximova, V. P., Zhidkova, E. M., Kirsanov, K. I., Lesovaya, E. A., Lobas, A. A., Gorshkov, M. V., Kovaleva, O. N., Milaeva, E. R., Galanski, M., Keppler, B. K. & Nazarov, A. A.
Bioinorganic Chemistry and Applications
(2017) 4736321

Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established
Kreutz, D., Bileck, A., Plessl, K., Wolrab, D., Groessl, M., Keppler, B. K., Meier, S. M. & Gerner, C.
Chemistry: A European Journal
(2017) 23, 8, S. 1881-1890

Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells
Domarco, O., Loetsch, D., Schreiber, J., Dinhof, C., Van Schoonhoven, S., Garcia, M. D., Peinador, C., Keppler, B. K., Berger, W. & Terenzi, A.
Dalton Transactions (Print Edition)
(2017) 46, 2, 329-332

 

Characterizing activation mechanisms and binding preferences of ruthenium metallo-prodrugs by a competitive binding assay
Artner, C., Holtkamp, H. U., Hartinger, C. G. & Meier-Menches, S. M.
Journal of Inorganic Biochemistry (2017) 177, 322-327

2016


Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling
Miklos, W., Heffeter, P., Pirker, C., Hager, S., Kowol, C. R., van Schoonhoven, S., Stojanovic, M., Keppler, B. K. & Berger, W.
Onco Target (2016) 7, 51, 84556-84574

DNA-Binding and Anticancer Activity of Pyrene-Imidazolium Derivatives
Bonsignore, R., Notaro, A., Salvo, A. M. P., Spinello, A., Fiasconaro, G., Terenzi, A., Giacalone, F., Keppler, B., Giuliano, M., Gruttadauria, M. & Barone, G.
Chemistry SELECT (2016) 1, 21, 6755–6761

Anticancer metal drugs and immunogenic cell death
Terenzi, A., Pirker, C., Keppler, B. K. & Berger, W.
Journal of Inorganic Biochemistry (2016) 165, 71-79

Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior
Hackl, C. M., Legina, M. S., Pichler, V., Schmidlehner, M., Roller, A., Domotor, O., Enyedy, E. A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Chemistry: A European Journal (2016) 22, 48, 17269-17281

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs
Karnthaler-Benbakka, C., Groza, D., Koblmueller, B., Terenzi, A., Holste, K., Haider, M., Baier, D., Berger, W., Heffeter, P., Kowol, C. R. & Keppler, B. K.
ChemMedChem (2016) 11, 21, 2410-2421

Towards targeting anticancer drugs: ruthenium(II)-arene complexes with biologically active naphthoquinone-derived ligand systems
Kubanik, M., Kandioller, W., Kim, K., Anderson, R. F., Klapproth, E., Jakupec, M. A., Roller, A., Sohnel, T., Keppler, B. K. & Hartinger, C. G.
Dalton Transactions (Print Edition) (2016) 45, 33, 13091-13103

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes
Bonsignore, R., Terenzi, A., Spinello, A., Martorana, A., Lauria, A., Almerico, A. M., Keppler, B. K. & Barone, G.
Journal of Inorganic Biochemistry (2016) 161, 115-121

Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes
Henke, H., Kryeziu, K., Banfic, J., Theiner, S., Körner, W., Brueggemann, O., Berger, W., Keppler, B., Heffeter, P. & Teasdale, I.
Macromolecular Bioscience (2016) 16, 8, 1239-1249

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention
Kowol, C. R., Miklos, W., Pfaff, S., Hager, S., Kallus, S., Pelivan, K., Kubanik, M., Enyedy, E. A., Berger, W., Heffeter, P. & Keppler, B. K.
Journal of Medicinal Chemistry (2016) 59, 14, 6739-6752

Biodistribution of the novel anticancer drug sodium trans-Retrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
Bytzek, A. K., Koellensperger, G., Keppler, B. K. & Hartinger, C. G.
Journal of Inorganic Biochemistry (2016) 160, 250-255

Differences in protein binding and excretion of Triapine and its Fe(III) complex
Pelivan, K., Miklos, W., Van Schoonhoven, S., Köllensperger, G., Gille, L., Berger, W., Heffeter, P., Kowol, C. & Keppler, B.
Journal of Inorganic Biochemistry (2016) 160, 61-69

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs
Göschl, S., Varbanov, H., Theiner, S., Jakupec, M., Galanski, M. & Keppler, B.
Journal of Inorganic Biochemistry (2016) 160, 264-274

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism
Bijelic, A., Theiner, S., Keppler, B. K. & Rompel, A.
Journal of Medicinal Chemistry (2016) 59, 12, 5894-5903

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles
Novak, M. S., Buechel, G. E., Keppler, B. K. & Jakupec, M. A.
Journal of Biological Inorganic Chemistry (2016) 21, 3, 347-356

Molecular mode of action of NKP-1339-a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines
Flocke, L. S., Trondl, R., Jakupec, M. A. & Keppler, B. K.
Investigational New Drugs (2016) 34, 3, 261-268

Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation
Schreiber-Brynzak, E., Pichler, V., Heffeter, P., Hanson, B., Theiner, S., Lichtscheidl-Schultz, I., Kornauth, C., Bamonti, L., Dhery, V., Groza, D., Berry, D., Berger, W., Galanski, M., Jakupec, M. A. & Keppler, B. K.
Metallomics (2016) 8, 4, 422-433

Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy
Wilfinger, N., Austin, S., Scheiber-Mojdekhar, B., Berger, W., Reipert, S., Praschberger, M., Paur, J., Trondl, R., Keppler, B. K., Zielinski, C. C. & Nowikovsky, K.
Onco Target (2016) 7, 2, 1242-1261

Another step toward DNA selective targeting: Ni-II and Cu-II complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes
Terenzi, A., Loetsch, D., van Schoonhoven, S., Roller, A., Kowol, C. R., Berger, W., Keppler, B. K. & Barone, G.
Dalton Transactions (Print Edition) (2016) 45, 18, 7758-7767     

Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics
Schmidlehner, M., Flocke, L. S., Roller, A., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (Print Edition) (2016) 45, 2, 724-733     

LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs
Theiner, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M., Koellensperger, G. & Keppler, B. K.
Metallomics (2016) 8, 4, 398-402

Multi-scale imaging of anticancer platinum(IV) compounds in murine tumor and kidney
Legin, A. A., Theiner, S., Schintlmeister, A., Reipert, S., Heffeter, P., Jakupec, M. A., Mayr, J., Varbanov, H. P., Kowol, C. R., Galanski, M., Berger, W., Wagner, M. & Keppler, B. K.
Chemical Science (2016) 7, 5, 3052-3061

Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity
Fischer, B., Kryeziu, K., Kallus, S., Heffeter, P., Berger, W., Kowol, C. R. & Keppler, B. K.
RSC Advances (2016) 6, 61, 55848-55859    

2015


Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling
Oehninger, L., Spreckelmeyer, S., Holenya, P., Meier, S. M., Can, S., Alborzinia, H., Schur, J., Keppler, B. K., Woefl, S. & Ott, I.
Journal of Medicinal Chemistry (2015) 58, 24, 9591-9600

Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy
Hoefer, D., Varbanov, H. P., Legin, A., Jakupec, M. A., Roller, A., Galanski, M. & Keppler, B. K.
Journal of Inorganic Biochemistry (2015) 153, 259-271

The rearrangement of tosylated flavones to 1 '-(alkylamino)aurones with primary amines
Kandioller, W., Kubanik, M., Bytzek, A. K., Jakupec, M. A., Roller, A., Keppler, B. K. & Hartinger, C. G.
Tetrahedron (2015) 71, 47, 8953-8959

Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2 '-bipyridine and ethylenediamine and their interaction with human serum albumin
Enyedy, E. A., Meszaros, J. P., Doemoetoer, O., Hackl, C. M., Roller, A., Keppler, B. K. & Kandioller, W.
Journal of Inorganic Biochemistry (2015) 152, 93-103

Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity
Kowol, C. R., Nagy, N. V., Jakusch, T., Roller, A., Heffeter, P., Keppler, B. K. & Enyedy, E. A.
Journal of Inorganic Biochemistry (2015) 152, 62-73

Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs
Schreiber-Brynzak, E., Klapproth, E., Unger, C., Lichtscheidl-Schultz, I., Goeschl, S., Schweighofer, S., Trondl, R., Dolznig, H., Jakupec, M. A. & Keppler, B. K.
Investigational New Drugs (2015) 33, 4, 835-847

Combination of Cadmium and High Cholesterol Levels as a Risk Factor for Heart Fibrosis
Tuerkcan, A., Scharinger, B., Grabmann, G., Keppler, B. K., Laufer, G., Bernhard, D. & Messner, B.
Toxicological Sciences (2015) 145, 2, 360-371

Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex
Habala, L., Bartel, C., Giester, G., Jakupec, M. A., Keppler, B. K. & Rompel, A.
Journal of Inorganic Biochemistry (2015) 147, 147-152

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance
Miklos, W., Pelivan, K., Kowol, C. R., Pirker, C., Dornetshuber-Fleiss, R., Spitzwieser, M., Englinger, B., van Schoonhoven, S., Cichna-Markl, M., Koellensperger, G., Keppler, B. K., Berger, W. & Heffeter, P.
Cancer Letters (2015) 361, 1, 112-120

Organometallic complexes of (thio)allomaltol-based Mannich-products: Synthesis, stability and preliminary biological investigations
Schmidlehner, M., Pichler, V., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Journal of Organometallic Chemistry (2015) 782, 69-76

Bis- and Tetrakis(carboxylato)platinum(IV) Complexes with Mixed Axial Ligands - Synthesis, Characterization, and Cytotoxicity
Hoffmeister, B. R., Hejl, M., Adib-Razavi, M. S., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Chemistry & Biodiversity (2015) 12, 4, 559-574

Bis- and Tris(carboxylato)platinum(IV) Complexes with Mixed Am(m)ine Ligands in the trans Position Exhibiting Exceptionally High Cytotoxicity
Hoffmeister, B. R., Hejl, M., Jakupec, M. A., Galanski, M. & Keppler, B. K. Apr 2015 in : European Journal of Inorganic Chemistry (2015) 10, 1700-1708

Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells
Babak, M. V., Plazuk, D., Meier, S. M., Arabshahi, H. J., Reynisson, J., Rychlik, B., Blauz, A., Szulc, K., Hanif, M., Strobl, S., Roller, A., Keppler, B. K. & Hartinger, C. G.
Chemistry: A European Journal (2015) 21, 13, 5110-5117

1,3-Dioxoindan-2-carboxamides as Bioactive Ligand Scaffolds for the Development of Novel Organometallic Anticancer Drugs
Mokesch, S., Novak, M. S., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Organometallics (2015) 34, 5, 848-857

Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application
Theiner, S., Varbanov, H. P., Galanski, M., Egger, A. E., Berger, W., Heffeter, P. & Keppler, B. K. Jan
Journal of Biological Inorganic Chemistry (2015) 20, 1, 89-99

Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins
Enyedy, E. A., Doemoetoer, O., Bali, K., Hetenyi, A., Tuccinardi, T. & Keppler, B. K.
Journal of Biological Inorganic Chemistry (2015) 20, 1, 77-88

Expanding on the Structural Diversity of Flavone- Derived Ruthenium II ( ƞ 6 -arene) Anticancer Agents
Kubanik, M., Tu, J. K. Y., Söhnel, T., Hejl, M., Jakupec, M., Kandioller, W., Keppler, B. & Hartinger, C. G.
Metallodrugs (2015) 1, 24-35

Extravasation of Pt-based chemotherapeutics - bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry ( LA-ICP-MS)
Egger, A. E., Kornauth, C., Haslik, W., Hann, S., Theiner, S., Bayer, G., Hartinger, C. G., Keppler, B. K., Pluschnigh, U. & Mader, R. M.
Metallomics (2015) 7, 3, 
508-515

Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential
Kuhn, P. -S., Pichler, V., Roller, A., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (Print Edition) (2015) 44, 2, 659-668

Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines
Pichler, V., Goeschl, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Metallomics (2015) 7, 7, 1078-1090

Solution equilibria and antitumor activities of pentamethylcyclopentadienyl rhodium complexes of picolinic acid and deferiprone
Enyedy, E. A., Doemoetoer, O., Hackl, C. M., Roller, A., Novak, M. S., Jakupec, M. A., Keppler, B. K. & Kandioller, W.
Journal of Coordination Chemistry (2015) 68, 9, 1583-1601

Speciation of metal-based nanomaterials in human serum characterized by capillary electrophoresis coupled to ICP-MS: a case study of gold nanoparticles
Matczuk, M., Anecka, K., Scaletti, F., Messori, L., Keppler, B. K., Timerbaev, A. R. & Jarosz, M.
Metallomics (2015) 7, 9, 1364-1370

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action
Babak, M. V., Meier, S. M., Huber, K. V. M., Reynisson, J., Legin, A. A., Jakupec, M. A., Roller, A., Stukalov, A., Gridling, M., Bennett, K. L., Colinge, J., Berger, W., Dyson, P. J., Superti-Furga, G., Keppler, B. K. & Hartinger, C. G.
Chemical Science (2015) 6, 4, 2449-2456

Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents
Theiner, S., Kornauth, C., Varbanov, H. P., Galanski, M., Van Schoonhoven, S., Heffeter, P., Berger, W., Egger, A. E. & Keppler, B. K.
Metallomics: (2015) 7, 8, 1256-1264

2014

New method for the speciation of ruthenium-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks
Martincic, A., Milacic, R., Vidmar, J., Turel, I., Keppler, B. K. & Scancar, J.
Journal of Chromatography A (2014) 1371, 168-176

Microwave-assisted synthesis of N-heterocycle-based organometallics
Schmidlehner, M., Kuhn, P-S., Hackl, C. M., Roller, A., Kandioller, W. & Keppler, B. K.
Journal of Organometallic Chemistry (2014) 772, 93-99

Modulation of Activity of Known Cytotoxic Ruthenium(III) Compound (KP418) with Hampered Transmembrane Transport in Electrochemotherapy In Vitro and In Vivo
Hudej, R., Miklavcic, D., Cemazar, M., Todorovic, V., Sersa, G., Bergamo, A., Sava, G., Martincic, A., Scancar, J., Keppler, B. K. & Turel, I.
Journal of Membrane Biology (2014) 247, 12, 1239-1251

Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation
Karnthaler-Benbakka, C., Groza, D., Kryeziu, K., Pichler, V., Roller, A., Berger, W., Heffeter, P. & Kowol, C. R.
Angewandte Chemie (International Edition) (2014) 53, 47, 12930-12935

Design, synthesis and comparative cytotoxic investigation of platinum(II) complexes with some derivatives of 5-methyl-5-(4-pyridyl)hydantoin
Bakalova, A., Buyukliev, R., Varbanov, H. & Momekov, G.
Inorganica Chimica Acta (2014) 423, 46-51

{Ru(CO)(x)}-core complexes with selected azoles: Synthesis, X-ray structure, spectroscopy, DFT analysis and evaluation of cytotoxic activity against human cancer cells
Tamasi, G., Carpini, A., Valensin, D., Messori, L., Pratesi, A., Scaletti, F., Jakupec, M., Keppler, B. & Cini, R.
Polyhedron (2014) 81, 227-237

Calpain-mediated integrin deregulation as novel mode of action for the anticancer gallium compound KP46. Molecular Cancer Therapeutics
Jungwirth, U., Gojo, J., Tuder, T., Walko, G., Holcmann, M., Schoefl, T., Nowikovsky, K., Wilfinger, N., Schoonhoven, S., Kowol, C. R., Lemmens, R., Heffeter, P., Keppler, B. K. & Berger, W.
Molecular Cancer Therapeutics (2014) 13, 10, 2436-2449

A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs
Varbanov, H. P., Goeschl, S., Heffeter, P., Theiner, S., Roller, A., Jensen, F., Jakupec, M. A., Berger, W., Galanski, M. & Keppler, B. K.
Journal of Medicinal Chemistry (2014) 57, 15, 6751-6764

Inductively coupled plasma mass spectrometry for metallodrug development: Albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes
Ossipov, K., Scaffidi-Domianello, Y. Y., Seregina, I. F., Galanski, M., Keppler, B. K., Timerbaev, A. R. & Bolshov, M. A.
Journal of Inorganic Biochemistry (2014) 137, 40-45

Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap versus Time-of-Flight Mass Analyzers
Meier, S. M., Babak, M. V., Keppler, B. K. & Hartinger, C. G.
ChemMedChem (2014) 9, 7, 1351-1355

Enhanced Anticancer Activity and Circumvention of Resistance Mechanisms by Novel Polymeric/Phospholipidic Nanocarriers of Doxorubicin
Senkiv, Y., Riabtseva, A., Heffeter, P., Boiko, N., Kowol, C. R., Jungwith, U., Shlyakhtina, Y., Garasevych, S. G., Mitina, N., Berger, W., Zaichenko, A. & Stoika, R.
Journal of Biomedical Nanotechnology. 10, 7, S. 1369-1381 13 S.

Can neutral analytes be concentrated by transient isotachophoresis in micellar electrokinetic chromatography and how much?
Matczuk, M., Foteeva, L. S., Jarosz, M., Galanski, M., Keppler, B. K., Hirokawa, T. & Timerbaev, A. R.
Journal of Chromatography A (2014) 1345, 212-218

Ruthenium(II)(eta(6)-arene) Complexes of Thiourea Derivatives: Synthesis, Characterization and Urease Inhibition
Hanif, M., Nawaz, M. A. H., Babak, M. V., Iqbal, J., Roller, A., Keppler, B. K. & Hartinger, C. G.
Molecules (2014) 19, 6, 8080-8092

Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: Synthesis, solution speciation and bioactivity
Doemoetoer, O., Aicher, S., Schmidlehner, M., Novak, M. S., Roller, A., Jakupec, M. A., Kandioller, W., Hartinger, C. G., Keppler, B. K. & Enyedy, E. A.
Journal of Inorganic Biochemistry (2014) 134, 57-65

Nanoformulation Improves Activity of the (pre)Clinical Anticancer Ruthenium Complex KP1019
Heffeter, P., Riabtseva, A., Senkiv, Y., Kowol, C. R., Koerner, W., Jungwith, U., Mitina, N., Keppler, B. K., Konstantinova, T., Yanchuk, I., Stoika, R., Zaichenko, A. & Berger, W.
Journal of Biomedical Nanotechnology (2014) 10, 5, 877-884

Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions*
Legin, A. A., Jakupec, M. A., Bokach, N. A., Tyan, M. R., Kukushkin, V. Y. & Keppler, B. K.
Journal of Inorganic Biochemistry (2014) 133, 33-39

Ruthenium-Nitrosyl Complexes with Glycine, L-Alanine, L-Valine, L-Proline, D-Proline, L-Serine, L-Threonine, and L-Tyrosine: Synthesis, X-ray Diffraction Structures, Spectroscopic and Electrochemical Properties, and Antiproliferative Activity
Rathgeb, A., Boehm, A., Novak, M. S., Gavriluta, A., Doemoetoer, O., Tornmasino, J. B., Enyedy, E. A., Shova, S., Meier, S., Jakupec, M. A., Luneau, D. & Arion, V. B.
Inorganic Chemistry (2014) 53, 5, 2718-2729

Triapine and a More Potent Dimethyl Derivative Induce Endoplasmic Reticulum Stress in Cancer Cells
Trondl, R., Flocke, L. S., Kowol, C. R., Heffeter, P., Jungwirth, U., Mair, G. E., Steinborn, R., Enyedy, E. A., Jakupec, M. A., Berger, W. & Keppler, B. K.
Molecular Pharmacology (2014) 85, 3, 451-459

Solution equilibrium studies of anticancer ruthenium(II)-eta(6)-p-cymene complexes of pyridinecarboxylic acids
Sija, E., Hartinger, C. G., Keppler, B. K., Kiss, T. & Enyedy, E. A.
Polyhedron (2014) 67, 51-58

Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity
Banfic, J., Legin, A. A., Jakupec, M. A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2014) 3, 484-492

Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent
Meier, S. M., Novak, M. S., Kandioller, W., Jakupec, M. A., Roller, A., Keppler, B. K. & Hartinger, C. G.
Dalton Transactions (Print Edition) (2014) 43, 26, 9851-9855

NanoSIMS combined with fluorescence microscopy as a tool for subcellular imaging of isotopically labeled platinum-based anticancer drugs
Legin, A. A., Schintlmeister, A., Jakupec, M. A., Galanski, M., Lichtscheidl-Schultz, I., Wagner, M. & Keppler, B. K.
Chemical Science (2014) 5, 8, 3135-3143

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
Trondl, R., Heffeter, P., Kowol, C. R., Jakupec, M. A., Berger, W. & Keppler, B. K.
Chemical Science (2014) 5, 8, 2925-2932

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation
Fischer, B., Heffeter, P., Kryeziu, K., Gille, L., Meier, S. M., Berger, W., Kowol, C. R. & Keppler, B. K.
Dalton Transactions (Print Edition) (2014) 43, 3, 1096-1104

Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice
Egger, A. E., Theiner, S., Kornauth, C., Heffeter, P., Berger, W., Keppler, B. K. & Hartinger, C.
Metallomics (2014) 6, 9, 1616-1625


2013


Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes
Hanif, M., Meier, S. M., Nazarov, A. A., Risse, J., Legin, A., Casini, A., Jakupec, M., Keppler, B. & Hartinger, C. G.
Frontiers in Chemistry (2013) 1, 27

Solution equilibria of anticancer ruthenium(II)-(eta(6)-p-cymene)-hydroxy(thio)pyr(id) one complexes: Impact of sulfur vs. oxygen donor systems on the speciation and bioactivity
Enyedy, E. A., Sija, E., Jakusch, T., Hartinger, C. G., Kandioller, W., Keppler, B. K. & Kiss, T.
Journal of Inorganic Biochemistry (2013) 127, 161-168

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo
Heffeter, P., Atil, B., Kryeziu, K., Groza, D., Koellensperger, G., Koerner, W., Jungwirth, U., Mohr, T., Keppler, B. K. & Berger, W.
European Journal of Cancer (2013) 49, 15,  3366-3375

p53 Increases Intra-Cellular Calcium Release by Transcriptional Regulation of Calcium Channel TRPC6 in GaQ(3)-Treated Cancer Cells
Madan, E., Gogna, R., Keppler, B. & Pati, U.
PLoS ONE (2013) 8, 8, 71016

A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2 '-deoxyguanosine 5'-monophosphate (dGMP)
Grabmann, G., Keppler, B. K. & Hartinger, C. G.
Analytical and Bioanalytical Chemistry (2013) 405, 20, 6417-6424

Bulky N(,N)-(Di)alkylethane-1,2-diamineplatinum(II) Compounds as Precursors for Generating Unsymmetrically Substituted Platinum(IV) Complexes
Pichler, V., Goeschl, S., Meier, S. M., Roller, A., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Inorganic Chemistry (2013) 52, 14, 8151-8162

Identification of the Structural Determinants for Anticancer Activity of a Ruthenium Arene Peptide Conjugate
Meier, S. M., Novak, M., Kandioller, W., Jakupec, M. A., Arion, V. B., Metzler-Nolte, N., Keppler, B. K. & Hartinger, C. G.
Chemistry: A European Journal (2013) 19, 28, 9297-9307

Platinum(IV) Complexes Featuring Axial (1,4-C-13(2))Succinato Ligands - Synthesis, Characterization, and Preliminary Investigations in Cancer Cell Lysates
Banfic, J., Adib Razavi, M. S., Galanski, M. & Keppler, B. K.
Zeitschrift für Anorganische und Allgemeine Chemie (2013)
639, 8-9, 1613-1620

Rhodium(Cp*) Compounds with Flavone-derived Ligand Systems: Synthesis and Characterization
Schwarz, M. B., Kurzwernhart, A., Roller, A., Kandioller, W., Keppler, B. K. & Hartinger, C. G.
Zeitschrift für Anorganische und Allgemeine Chemie (2013) 639, 8-9, 1648-1654

Am(m)ines Make the Difference: Organoruthenium Am(m)ine Complexes and Their Chemistry in Anticancer Drug Development
Babak, M., Meier, S. M., Legin, A., Adib Razavi, M. S., Roller, A., Jakupec, M., Keppler, B. & Hartinger, C. G.
Chemistry: A European Journal (2013)
19, 13, 4308-4318

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies
Domotor, O., Hartinger, C. G., Bytzek, A., Kiss, T., Keppler, B. & Enyedy, E. A.
Journal of Biological Inorganic Chemistry (2013) 18, 1, 9-17

Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes
Valiahdi, S. M., Egger, A., Miklos, W., Jungwirth, U., Meelich, K., Berger, W., Hartinger, C. G., Galanski, M., Jakupec, M. & Keppler, B.
Journal of Biological Inorganic Chemistry (2013) 18, 2, 249-260

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery
Pichler, V., Mayr, J., Heffeter, P., Domotor, O., Enyedy, E. A., Hermann, G., Groza, D., Köllensperger, G., Galanski, M., Berger, W., Keppler, B. & Kowol, C.
Chemical Communications (2013) 49, 22, 2249-2251

Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation
Filak, L., Göschl, S., Heffeter, P., Egger, A., Jakupec, M., Keppler, B., Berger, W. & Arion, V.
Organometallics (2013) 32, 3, 903-914

Novel metal(II) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents
Meier, S. M., Adhireksan, Z., Pichler, V., Novak, M., Jirkovsky, E., Jakupec, M., Arion, V., Davey, C. A., Keppler, B. & Hartinger, C.
Chemical Science (2013) 4, 4, 1837-1846

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity
Kandioller, W., Balsano, E., Meier, S. M., Jungwirth, U., Göschl, S., Roller, A., Jakupec, M., Berger, W., Keppler, B. & Hartinger, C. G.
Chemical Communications (2013) 49, 32, 3348-3350

Solution equilibrium studies on anticancer ruthenium(II)-eta(6)-p-cymene complexes of 3-hydroxy-2(1H)-pyridones
Enyedy, E. A., Bognar, G. M., Kiss, T. & Hartinger, C.
Journal of Organometallic Chemistry (2013) 734, SI, 38-44

Striking Difference in Antiproliferative Activity of Ruthenium- and Osmium-Nitrosyl Complexes with Azole Heterocycles
Büchel, G., Gavriluta, A., Novak, M., Meier, S. M., Jakupec, M., Cuzan, O., Turta, C., Tommasino, J. B., Jeanneau, E., Novitchi, G., Luneau, D. & Arion, V.
Inorganic Chemistry (2013) 52, 11, 6273-6285

Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
Kryeziu, K., Jungwirth, U., Hoda, M. A., Ferk, F., Karnthaler-Benbakka, C., Knasmüller, S., Kowol, C., Berger, W. & Heffeter, P.
Molecular Cancer Therapeutics (2013) 12, 6, 1073-1084

Theoretical Investigations and Density Functional Theory Based Quantitative Structure-Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes
Varbanov, H., Jakupec, M., Roller, A., Jensen, F., Galanski, M. & Keppler, B.
Journal of Medicinal Chemistry (2013) 56, 1, 330-344

X-ray Absorption Near Edge Structure Spectroscopy to Resolve the in Vivo Chemistry of the Redox-Active Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019)
Hummer, A., Heffeter, P., Berger, W., Filipits, M., Batchelor, D., Büchel, G., Jakupec, M., Keppler, B. & Rompel, A.
Journal of Medicinal Chemistry (2013) 56, 3, 1182-1196

3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru-II(arene) anticancer complexes with biologically active ligands
Kurzwernhart, A., Kandioller, W., Enyedy, E. A., Novak, M., Jakupec, M., Keppler, B. & Hartinger, C. G.
Dalton Transactions (Print Edition) (2013) 42, 17, 6193-6202

Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs
Hartinger, C. G., Größl, M., Meier, S. M., Casini, A. & Dyson, P. J.
Chemical Society Reviews (2013) 42, 14, 6186-6199