o. Univ.-Prof. Dr. Dr. Bernhard Keppler

Email: bernhard.keppler@univie.ac.at
Phone: +43-1-4277-52602

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Publications


Rational development of oxaliplatin analogues - Synthesis and preliminary structure-activity relationships. / Galanski, Mathea Sophia; Habala, Ladislav; Nazarov, Alexey et al.
In: International Journal of Clinical Pharmacology and Therapeutics, Vol. 43, No. 12, 2005, p. 575-576.

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Reactions of potent antitumor complex trans-[RuIIICl 4(indazole)2]- with a DNA-relevant nucleobase and thioethers: Insight into biological action. / Egger, Alexander; Arion, Vladimir (Corresponding author); Reisner, Erwin et al.
In: Inorganic Chemistry, Vol. 44, No. 1, 2005, p. 122-132.

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Redox-active antineoplastic ruthenium complexes with indazole: Correlation of in vitro potency and reduction potential. / Jakupec, Michael; Reisner, Erwin; Eichinger, Anna et al.
In: Journal of Medicinal Chemistry, Vol. 48, No. 8, 2005, p. 2831-2837.

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Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives. / Habala, Ladislav; Galanski, Mathea Sophia; Yasemi, Afshin et al.
In: European Journal of Medicinal Chemistry, Vol. 40, No. 11, 2005, p. 1149-1155.

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Synthesis, cytotoxicity, and structure-activity relationships of new oxaliplatin derivatives. / Galanski, Mathea Sophia (Corresponding author); Yasemi, Afshin; Jakupec, Michael et al.
In: Monatshefte für Chemie, Vol. 136, No. 5, 2005, p. 693-700.

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The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells. / Kapitza, S; Jakupec, Michael; Uhl, Maria et al.
In: Cancer Letters, Vol. 226, No. 2, 2005, p. 115-121.

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Tuning of Redox Properties for the Design of Ruthenium Anticancer Drugs:  Part 2. Syntheses, Crystal Structures, and Electrochemistry of Potentially Antitumor [RuIII/IICl6-n(Azole)n]z (n = 3, 4, 6) Complexes. / Reisner, Erwin; Arion, Vladimir; Eichinger, Anna et al.
In: Inorganic Chemistry, Vol. 44, No. 19, 2005, p. 6704-6716.

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Two dimensional separation schemes for investigation of the interaction of an anticancer ruthenium(III) compound with plasma proteins. / Sulyok, Michael; Hann, Stephan; Hartinger, Christian et al.
In: Journal of Analytical Atomic Spectrometry, Vol. 20, No. 9, 2005, p. 856-863.

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1,1'-Bis(oxazolin-2-yl)ferrocenes: An investigation of their complexation behavior toward [Pd(?3-allyl)Cl]2. / Hartinger, Christian; Nazarov, Alexey; Arion, Vladimir et al.
In: European Journal of Inorganic Chemistry, No. 8, 2005, p. 1589-1600.

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A comparative study of adduct formation between the anticancer ruthenium(III) compound HInd trans-[RuCl4(Ind)2] and serum proteins. / Piccioli, F; Sabatini, S; Messori, Luigi (Corresponding author) et al.
In: Journal of Inorganic Biochemistry, Vol. 98, No. 6, 2004, p. 1135-1142.

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Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: Indications of guanosine 5'-monophosphate O6-N7 chelation. / Warnke, Ulrich; Rappel, Christina; Meier, Heiko et al.
In: ChemBioChem: a european journal of chemical biology, Vol. 5, No. 11, 2004, p. 1543-1549.

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First data on structure-activity relations for the antitumor complexes [RuCl4(azole)2]. / Reisner, Erwin; Arion, Vladimir; Keppler, Bernhard et al.
In: Russian Chemical Journal, Vol. 48, No. 4, 2004, p. 137-139.

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Gallium in cancer treatment. / Jakupec, Michael; Keppler, Bernhard (Corresponding author).
In: Current Topics in Medicinal Chemistry, Vol. 4, No. 15, 2004, p. 1575-1583.

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Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: Characterization of interactions between Pt(II) complexes and human serum albumin. / Timerbaev, Andrei; Aleksenko, Svetlana S.; Polec-Pawlak, Katarzyna et al.
In: Electrophoresis, Vol. 25, No. 13, 2004, p. 1988-1995.

Publications: Contribution to journalArticlePeer Reviewed


Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible. / Galanski, Mathea Sophia; Yasemi, Afshin; Slaby, Susanna et al.
In: European Journal of Medicinal Chemistry, Vol. 39, No. 8, 2004, p. 707-714.

Publications: Contribution to journalArticlePeer Reviewed