o. Univ.-Prof. Dr. Dr. Bernhard Keppler

Email: bernhard.keppler@univie.ac.at
Phone: +43-1-4277-52602

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Publications


Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex. / Hudej, Rosana; Kljun, Jakob; Kandioller, Wolfgang et al.
In: Organometallics, Vol. 31, No. 16, 2012, p. 5867-5874.

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Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder. / Kurzwernhart, Andrea; Kandioller, Wolfgang; Bartel, Caroline et al.
In: Chemical Communications, Vol. 48, No. 40, 2012, p. 4839-4841.

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Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: Synthesis, characterization, and biological activity. / Pichler, Verena; Heffeter, Petra; Valiahdi, Seied Mojtaba et al.
In: Journal of Medicinal Chemistry, Vol. 55, No. 24, 2012, p. 11052-11061.

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Water-Soluble Cationic Derivatives of Indirubin, the Active Anticancer Component from Indigo naturalis. / Ginzinger, Werner; Egger, Alexander; Mühlgassner, Gerhard et al.
In: Chemistry & Biodiversity, Vol. 9, No. 10, 2012, p. 2175-2185.

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X-ray Absorption Spectroscopy of an Investigational Anticancer Gallium(III) Drug: Interaction with Serum Proteins, Elemental Distribution Pattern, and Coordination of the Compound in Tissue. / Hummer, Alfred; Bartel, Caroline; Arion, Vladimir et al.
In: Journal of Medicinal Chemistry, Vol. 55, No. 11, 2012, p. 5601-5613.

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Microfluidic preparation of [F-18]FE@SUPPY and [F-18]FE@SUPPY:2 - comparison with conventional radiosyntheses. / Ungersböck, Johanna; Philippe, Cecile; Mien, Leonhard Key et al.
In: Nuclear Medicine and Biology, Vol. 38, No. 3, 04.2011, p. 427-434.

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From hydrolytically labile to hydrolytically stable Ru-II-arene anticancer complexes with carbohydrate-derived co-ligands. / Hanif, Muhammad; Meier, Samuel M.; Kandioller, Wolfgang et al.
In: Journal of Inorganic Biochemistry, Vol. 105, No. 2, 02.2011, p. 224-231.

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A polymer inclusion membrane based on the ionic liquid trihexyl(tetradecyl)phosphonium chloride and PVC for solid-liquid extraction of Zn(II) from hydrochloric acid solution. / Kogelnig, Daniel (Corresponding author); Stojanovic, Anja; Jirsa, Franz et al.
In: Monatshefte für Chemie, Vol. 142, No. 8, 2011, p. 769-772.

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A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography. / Foteeva, Lidia S.; Trofimov, Denis A.; Kuznetsova, Olga V. et al.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 55, No. 3, 2011, p. 409-413.

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Anticancer Activity of Metal Complexes: Involvement of Redox Processes. / Kowol, Christian; Keppler, Bernhard; Hartinger, Christian et al.
In: Antioxidants and Redox Signaling, Vol. 15, No. 4, 2011, p. 1085-1127.

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Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells. / Stepanenko, Iryna; Casini, Angela; Edafe, Fabio et al.
In: Inorganic Chemistry, Vol. 50, No. 24, 2011, p. 12669-12679.

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En Route to Osmium Analogues of KP1019: Synthesis, Structure, Spectroscopic Properties and Antiproliferative Activity of trans-[Os(IV)Cl(4)(Hazole)(2)]. / Büchel, Gabriel; Stepanenko, Iryna; Hejl, Michaela et al.
In: Inorganic Chemistry, Vol. 50, No. 16, 2011, p. 7690-7697.

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Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes? / Buß, Irina; Garmann, Dirk; Galanski, Mathea Sophia et al.
In: Journal of Inorganic Biochemistry, Vol. 105, No. 5, 2011, p. 709-717.

Publications: Contribution to journalArticlePeer Reviewed


Hydroxy and ether functionalized dithiolanes: Models for the active site of the [FeFe] hydrogenase. / Apfel, Ulf-Peter; Kowol, Christian; Kloss, Florian et al.
In: Journal of Organometallic Chemistry, Vol. 696, No. 5, 2011, p. 1084-1088.

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Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019. / Bartel, Caroline; Jakupec, Michael (Corresponding author); Heffeter, Petra et al.
In: Journal of Biological Inorganic Chemistry, Vol. 16, No. 8, 2011, p. 1205-1215.

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Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study. / Enyedy, Eva Anna (Corresponding author); Primik, Michael; Kowol, Christian et al.
In: Dalton Transactions, Vol. 40, No. 22, 2011, p. 5895-5905.

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Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies. / Enyedy, Eva Anna (Corresponding author); Horvath, Laszlo; Hetenyi, Anasztazia et al.
In: Bioorganic & Medicinal Chemistry, Vol. 19, No. 14, 2011, p. 4202-4210.

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Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water. / Fischer, Lisa; Falta, Thomas; Köllensperger, Gunda et al.
In: Water Research, Vol. 45, No. 15, 2011, p. 4601-4614.

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LC- and CZE-ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma. / Bytzek, Anna; Böck, Katharina; Hermann, Gerrit et al.
In: Metallomics: integrated biometal science, Vol. 3, No. 10, 2011, p. 1049-1055.

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Lectin Conjugates as Biospecific Contrast Agents for MRI. Coupling of Lycopersicon esculentum Agglutinin to Linear Water-Soluble DTPA-Loaded Oligomers. / Pashkunova-Martic, Irena; Kremser, Christian; Galanski, Mathea Sophia et al.
In: Molecular Imaging and Biology, Vol. 13, No. 3, 2011, p. 432-442.

Publications: Contribution to journalArticlePeer Reviewed