Assoz. Prof. Mag. Dr. Christian Kowol

Prodrug Development, Drug Delivery Systems, Drug Targeting

Phone: +43 1 4277 52609
Email: christian.kowol@univie.ac.at
Währinger Straße 42, Room 2H15

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Research Focus

Chemotherapy and therapy with small targeted molecules are two major strategies for treatment of human cancer at the disseminated stage. However, even when using new targeted drugs, the therapy is often limited by severe side effects, resistance development and insufficient tumor accumulation.

The research of my group focuses on the development of new strategies to overcome these limitations:

  • Bioinorganic prodrug development of clinically approved drugs to prevent the occurrence of severe side effects (for a press release click here)
  • Drug delivery systems like nanoparticles, liposomes, polymers for tumor-specific accumulation and activation of anticancer drugs
  • Drug targeting strategies using tumor-specific peptides

All research projects are highly interdisciplinary and are developed in close cooperation with the Institute of Cancer Research of the Medical University of Vienna within the Research Cluster “Translational Cancer Therapy Research”.

Awards

2016 Förderpreis of the Vienna Fund for Innovative Interdisciplinary Cancer Research for the publication “Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation"

2014 INiTS Award, 1st place for “Tumor-specific, Hypoxia-based Activation of EGFR-Inhibitors”

2014 RIZ GENIUS Award, 3rd place for “Tumor-specific Tyrosinkinase Inhibitors for Efficient Cancer Therapy”

2011 Forschungsentwicklungspreis of the Vienna Fund for innovative interdisciplinary cancer research

2010 Bank Austria Award to support innovative research projects (Preis zur Förderung innovativer Forschungsprojekte)

Scientific Collaborations

KARST, Uwe, University of Münster, Germany

ENYEDY, Éva Anna, University of Szeged, Hungary

GALAMBA CORREIA, João, University of Lisbon, Portugal

TEASDALE, Ian, Johannes Kepler University Linz, Austria

Team

Dipl.-Ing. Marlene Mathuber
Metal-based Anticancer Prodrugs

Phone: +43 1 4277 52616
Email: marlene.mathuber@univie.ac.at
Währinger Straße 42, Room 2H16

Björn Bielec, MSc.
Anticancer Prodrugs

Phone:+43 1 4277 52616
Email: bjoern.bielec@univie.ac.at
Währinger Straße 42, Room 2H16

Philipp Fronik, MSc MSc
Metal-based Anticancer Prodrugs

Phone: +43 1 4277 52616
Email: philipp.fronik@univie.ac.at
Währinger Straße 42, Room 2H16

Alexander Kastner, MSc
Metal-based Anticancer prodrugs

Email: alexander.kastner@univie.ac.at
Phone: +43 1 4277 52616
Währinger Straße 42, Room 2H16

Anja Federa, BSc.
Anticancer tyrosine kinase inhibitor prodrugs

 

 

Alexander Unterlercher, BSc.
Anticancer thiosemicarbazone prodrug systems

Former Team Members

  • Sebastian Kallus (PhD Student)
    Drug delivery systems for cancer therapy
  • Karla Pelivan (PhD Student)
    Bioanalytical investigations of thiosemicarbazone anticancer drugs
  • Marianne Lahnsteiner (Master's Student)
    Synthesis and reactivity of thiol-targeting moieties for drug delivery
  • Florian Bachmann (Master's Student)
    Novel albumin-targeting platinum anticancer complexes
  • Julia Nunes (Visiting PhD Student, Department of Inorganic Chemistry Department, University of Campinas (UNICAMP), Brazil)