Publications


2022


Simple synthesis of massively parallel RNA microarrays via enzymatic conversion from DNA microarrays
Schaudy, E., Hölz K., Lietard, J. & Somoza, M.M.
Nature Communications (2022) 13, 3772

Sequence-dependence of Cy3 and Cy5 dyes in 3' terminally-labeled single-stranded DNA
Kekic, T. & Lietard, J.
Scientific Reports (2022) 12, 1, 14803

An 8-bit monochrome palette of fluorescent nucleic acid sequences for DNA-based painting
Kekic, T. & Lietard, J.
Nanoscale (2022) 14, 17528-17533

Sequence-dependent quenching of fluorescein fluorescence on single-stranded and double-stranded DNA
Lietard, J., Ameur, D. & Somoza, M. M.
RSC Adv.(2022) 12, 9, 5629-5637

Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice
Lieder, B., Conka, J., Mistlberger-Reiner, A., Zabel, V., Ameur, D., Somoza, M. M., Sebekova, K., Celec, P. & Somoza, V.
Nutrients (2022) 14, 3, 594

Defining the Sphagnum Core Microbiome across the North American Continent Reveals a Central Role for Diazotrophic Methanotrophs in the Nitrogen and Carbon Cycles of Boreal Peatland Ecosystems
Kolton, M., Weston, D. J., Mayali, X., Weber, P. K., McFarlane, K. J., Pett-Ridge, J., Somoza, M. M., Lietard, J., Glass, J. B., Lilleskov, E. A., Shaw, A. J., Tringe, S., Hanson, P. J. & Kostka, J. E.
mBio (2022) 13, 1, e03714-21

Reducing the Bitter Taste of Pharmaceuticals Using Cell-Based Identification of Bitter-Masking Compounds
Beltrán Márquez, L. R., Sterneder, S., Hasural, A., Paetz, S., Hans, J., Ley, J. P. & Somoza, V.
Pharmaceuticals (2022) 15, 3, 317

 


2021


Bitter Sensing TAS2R50 Mediates the trans-Resveratrol-Induced Anti-inflammatory Effect on Interleukin 6 Release in HGF-1 Cells in Culture
Tiroch, J., Sterneder, S., Di Pizio, A., Lieder, B., Hoelz, K., Holik, A. K., Pignitter, M., Behrens, M., Somoza, M., Ley, J. P. & Somoza, V.
Journal of Agricultural and Food Chemistry (2021) 69, 45, 13339-13349

Sequence Preference and Initiator Promiscuity for De Novo DNA Synthesis by Terminal Deoxynucleotidyl Transferase
Schaudy, E., Lietard, J. & Somoza, M. M.
ACS Synthetic Biology (2021) 10, 7, 1750-1760

Chemical and photochemical error rates in light-directed synthesis of complex DNA libraries
Lietard, J., Leger, A., Erlich, Y., Sadowski, N., Timp, W. & Somoza, M. M.
Nucleic Acids Research (2021) 49, 12, 6687-6701

Gastric Serotonin Biosynthesis and Its Functional Role in L-Arginine-Induced Gastric Proton Secretion
Holik, A-K., Schweiger, K., Stoeger, V., Lieder, B., Reiner, A., Zopun, M., Hoi, J. K., Kretschy, N., Somoza, M. M., Kriwanek, S., Pignitter, M. & Somoza, V.
International Journal of Molecular Sciences (2021) 22, 11, 5881

 

 


2020


Low cost DNA data storage using photolithographic synthesis and advanced information reconstruction and error correction
Antkowiak, P. L., Lietard, J., Darestani, M. Z., Somoza, M. M., Stark, W. J., Heckel, R. & Grass, R. N.
Nature Communications (2020) 11, 1, 5345

l-DNA Duplex Formation as a Bioorthogonal Information Channel in Nucleic Acid-Based Surface Patterning
Schaudy, E., Somoza, M. M. & Lietard, J.
Chemistry: A European Journal (2020) 26, 63, 14310-14314

Melanoidins from coffee and bread differently influence energy intake: A randomized controlled trial of food intake and gut-brain axis response
Walker, J. M., Mennella, I., Ferracane, R., Tagliamonte, S., Holik, A-K., Hoelz, K., Somoza, M. M., Somoza, V., Fogliano, V. & Vitaglione, P.
Journal of Functional Foods (2020) 72, 104063

Bitter-Tasting Amino Acids L-Arginine and L-Isoleucine Differentially Regulate Proton Secretion via T2R1 Signaling in Human Parietal Cells in Culture
Stoeger, V., Holik, A-K., Hoelz, K., Dingjan, T., Hans, J., Ley, J. P., Krammer, G. E., Niv, M. Y., Somoza, M. M. & Somoza, V.
Journal of Agricultural and Food Chemistry (2020) 68, 11, 3434-3444

 


2019


Specificity and Efficiency of the Uracil DNA Glycosylase-Mediated Strand Cleavage Surveyed on Large Sequence Libraries
Hoelz, K., Pavlic, A., Lietard, J. & Somoza, M. M.
Scientific Reports (2019) 9, 17822

Spotting, Transcription and In Situ Synthesis: Three Routes for the Fabrication of RNA Microarrays
Lietard, J., and Somoza, M. M.
Computational and Structural Biotechnology (2019) 17, 862-868

Large-scale photolithographic synthesis of chimeric DNA/RNA hairpin microarrays to explore sequence specificity landscapes of RNase HII cleavage
Lietard, J., Damha, M. J. & Somoza, M. M.
Biochemistry (2019) 58, 44, 4389-4397

Exposure of Human Gastric Cells to Oxidized Lipids Stimulates Pathways of Amino Acid Biosynthesis on a Genomic and Metabolomic Level
Zaunschirm, M., Pignitter, M., Kopic, A., Kessler, C., Hochkogler, C., Kretschy, N., Somoza, M. M. & Somoza, V.
Molecules (2019) 24, 22

Identification of cinnamaldehyde as most effective fatty acid uptake reducing cinnamon-derived compound in differentiated Caco-2 cells compared to its structural analogs cinnamyl alcohol, cinnamic acid and cinnamyl isobutyrate
Hoi, J. K., Lieder, B., Pignitter, M., Hans, J., Ley, J. P., Lietard, J., Hölz, K., Somoza M. M. & Somoza, V.
Journal of Agricultural and Food Chemistry (2019) 67, 42, 11638-11649

Chip-SIP: stable isotope probing analyzed with rRNA-targeted microarrays and NanoSIMS
Mayali, X., Weber, P. K., Nuccio, E., Lietard, J., Somoza, M., Blazewicz, S. J. & Pett-Ridge, J.
in "Stable Isotope Probing: Methods and Protocols", Methods in Molecular Biology 2019, vol. 2046

Multi-level patterning nucleic acid photolithography
Hoelz, K., Schaudy, E., Lietard, J. & Somoza, M. M., 23 Aug 2019
Nature Communications (2019) 10, 3805

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
Lietard, J., Schaudy, E., Hölz, K., Ameur, D. & Somoza, M. M.
Journal of Visualized Experiments (2019) 150, 59936

Advances in Light‐Directed Synthesis of High‐Density Microarrays and Extension to RNA and 2′F‐ANA Chemistries
Lietard, J., Damha, M. J. & Somoza, M. M.
in: Fernández‐Lucas, J. (Ed.), Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives. Wiley-VCH Verlag GmbH & Co. KGaA, 291-312

 


2018


The advanced glycation end product N-epsilon-carboxymethyllysine and its precursor glyoxal increase serotonin release from Caco-2 cells
Holik, A-K., Lieder, B., Kretschy, N., Somoza, M. M., Ley, J. P., Hans, J. & Somoza, V.
Journal of Cellular Biochemistry (2018) 119, 3, 2731-2741

Impact of free N-epsilon-carboxymethyllysine, its precursor glyoxal and AGE-modified BSA on serotonin release from human parietal cells in culture
Holik, A-K., Stoeger, V., Hoelz, K., Somoza, M. M. & Somoza, V.
Food & Function (2018) 9, 7, 3906-3915

High-Efficiency Reverse (5 '-> 3 ') Synthesis of Complex DNA Microarrays
Hoelz, K., Hoi, J. K., Schaudy, E., Somoza, V., Lietard, J. & Somoza, M. M.
Scientific Reports (2018) 8, 15099

High-Density RNA Microarrays Synthesized In Situ by Photolithography
Lietard, J., Ameur, D., Damha, M. J. & Somoza, M. M.
Angewandte Chemie - International Edition (2018) 57, 46, 15257-15261

 


2017


Hamming Distance as a Concept in DNA Molecular Recgonition
Mohammadi-Kambs, M., Hölz, K., Somoza, M. M. & Ott, A.
ACS Omega
(2017) 2, 4, 1302-1308

Mapping the affinity landscape of Thrombin-binding aptamers on 2 ' F-ANA/DNA chimeric G-Quadruplex microarrays
Lietard, J., Abou Assi, H., Gomez-Pinto, I., Gonzalez, C., Somoza, M. M. & Damha, M. J.
Nucleic Acids Research
(2017) 45, 4, 1619-1632

In vitro combinatory effects of the Alternaria mycotoxins alternariol and altertoxin II and potentially involved miRNAs
Vejdovszky, K., Sack, M., Jarolim, K., Aichinger, G., Somoza, M. M. & Marko, D.
Toxicology Letters
(2017) 267, 45-52

High-Power 365 nm UV LED Mercury Arc Lamp Replacement for Photochemistry and Chemical Photolithography
Hölz, K., Lietard, J. & Somoza, M. M.
ACS Sustainable Chemistry & Engineering
(2017) 5, 1, 828-834

Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells
Liszt, K. I., Ley, J. P., Lieder, B., Behrens, M., Stoeger, V., Reiner-Concin, A., Hochkogler, C. M., Koeck, E., Marchiori, A., Hans, J., Widder, S., Krammer, G., Sanger, G. J., Somoza, M. M., Meyerhof, W. & Somoza, V.
Proceedings of the National Academy of Sciences of the United States of America (PNAS) 
(2017) 114, 30, E6260-E6269


2016


N ϵ -Carboxymethyllysine Increases the Expression of miR-103/143 and Enhances Lipid Accumulation in 3T3-L1 Cells
Holik, A-K., Lieder, B., Kretschy, N., Somoza, M. M., Held, S. & Somoza, V.
Journal of Cellular Biochemistry (2016) 117, 10, 2413-2422

Express photolithographic DNA microarray synthesis with optimized chemistry and high-efficiency photolabile groups
Sack, M., Hoelz, K., Holik, A-K., Kretschy, N., Somoza, V., Stengele, K-P. & Somoza, M. M.
Journal of Nanobiotechnology (2016) 14, 13, 14

Sequence-Dependent Fluorescence of Cy3-and Cy5-Labeled Double-Stranded DNA
Kretschy, N., Sack, M. & Somoza, M. M.
Bioconjugate Chemistry (2016) 27, 3, 840-848

Evaluation of Palm Oil as a Suitable Vegetable Oil for Vitamin A Fortification Programs
Pignitter, M., Hernler, N., Zaunschirm, M., Kienesberger, J., Somoza, M. M., Kraemer, K. & Somoza, V.
Nutrients (2016) 8, 6, 378


2015


Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis
Kretschy, N., Holik, A-K., Somoza, V., Stengele, K-P.
& Somoza, M. M.
Angewandte Chemie (International Edition) (2015) 54, 29, 8555-8559

o-Nitrobenzyl-photolabile Gruppen der nächsten Generation in der lichtgesteuerten Chemie und der Synthese von Mikroarrays
Somoza, M. M., Kretschy, N., Holik, A-K., Somoza, V. & Stengele, K-P. 3
Angewandte Chemie (2015) 127, 29, 8675–8679

Nonivamide Enhances miRNA let-7d Expression and Decreases Adipogenesis PPAR gamma Expression in 3T3-L1 Cells
Rohm, B., Holik, A-K., Kretschy, N., Somoza, M. M., Ley, J. P., Widder, S., Krammer, G. E., Marko, D. & Somoza, V.
Journal of Cellular Biochemistry (2015) 116, 6, 1153-1163


 2014


Comparison of the Sequence-Dependent Fluorescence of the Cyanine Dyes Cy3, Cy5, DyLight DY547 and DyLight DY647 on Single-Stranded DNA
Kretschy, N. & Somoza, M. M.
PLoS ONE (2014) 9, 1, e85605

Base-cleavable microarrays for the characterization of DNA and RNA oligonucleotides synthesized in situ by photolithography
Lietard, J., Kretschy, N., Sack, M., Wahba, A. S., Somoza, M. M. & Damha, M. J.
Chemical Communications (2014) 50, 85, 12903-12906


2013


Nonivamide, a capsaicin analog, increases dopamine and serotonin release in SH-SY5Y cells via a TRPV1-independent pathway
Rohm, B., Holik, A-K., Somoza, M. M., Pignitter, M., Zaunschirm, M., Ley, J. P., Krammer, G. E. & Somoza, V.
Molecular Nutrition & Food Research (2013) 57, 11, 2008-2018

Simultaneous Light-Directed Synthesis of Mirror-Image Microarrays in a Photochemical Reaction Cell with Flare Suppression
Sack, M., Kretschy, N., Rohm, B., Somoza, V. & Somoza, M. M.
Analytical Chemistry (2013) 85, 18, 8513-8517

N-ε-Carboxymethyllysine (CML), a Maillard reaction product, stimulates serotonin release and activates the receptor for advanced glycation end products (RAGE) in SH-SY5Y cells
Holik, A-K., Rohm, B., Somoza, M. M. & Somoza, V.
Food & Function (2013) 4, 7, 1111-1120

Optimized Light-Directed Synthesis of Aptamer Microarrays
Franssen-van Hal, N. L. W., van der Putte, P., Hellmuth, K., Matysiak, S., Kretschy, N. & Somoza, M. M.
Analytical Chemistry (2013) 85, 12, 5950-5957